ATP2C2 antibody (N-Term)

Catalog No. ABIN1888109

Product Details anti-ATP2C2 Antibody

Target: ATP2C2 (ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATP2C2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Cross-Reactivity (Details): At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the amino terminus of human ATP2C2.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for ATP2C2

Target: ATP2C2 (ATPase, Ca++ Transporting, Type 2C, Member 2 (ATP2C2))

Alternative Name: ATP2C2 (ATP2C2 Products)

Synonyms: KIAA0703 antibody, MGC146612 antibody, SPCA2 antibody, 1810010G06Rik antibody, Spca2 antibody, mKIAA0703 antibody, ATPase secretory pathway Ca2+ transporting 2 antibody, ATPase, Ca++ transporting, type 2C, member 2 S homeolog antibody, ATPase, Ca++ transporting, type 2C, member 2 antibody, ATP2C2 antibody, atp2c2.S antibody, atp2c2 antibody, Atp2c2 antibody

Background: ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases.This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen.Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles.Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation.Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
Synonyms: Calcium-transporting ATPase type 2C member 2, PMR1, SPCA2, hSPCA2

NCBI Accession: NP_055676

Pathways: Ribonucleoside Biosynthetic Process