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Details for Product No. ABIN188986

TAR DNA Binding Protein (TARDBP) antibody

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Antigen
Synonyms ALS10, TDP-43, Tdp43, C85084, 1190002A23Rik, wu:fb77f02, wu:fc52g10, TARDBP, TDP43, DKFZp459I2127, tardbp
Reactivity
»Alternatives Chicken, Human, Monkey, Mouse (Murine), Xenopus laevis, Zebrafish (Danio rerio)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN188986
Quantity 0.1 mL
Price
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Immunogen A synthetic peptide to a C-terminal region [within residues 350-414] of the humanTARDBP protein. [Swiss-Prot# Q13148].
Specificity Species Reactivity: Reacts with human, primate, mouse, chicken, Xenopus, and Zebrafish. Localization: Nuclear.
Cross-Reactivity Human
Purification Affinity Purified
Alternative Name TARDBP
Background The HIV1 virus gives rise to acquired immunodeficiency syndrome (AIDS). HIV1contains an RNA genome which produces chromosomally integrated DNA duringcellular replication. Gene activation of HIV1 by the transactivator Tat requires an RNAregulatory element TAR which is located downstream of the transcription initiation site.TARDBP is a transcriptional repressor that binds to the chromosomally integrated TARDNA, preventing HIV1 expression. Additionally, this protein regulates alternative splicingof the CTFR gene, a similar pseudogene on chromosoome 20. TARDBP has also been recently been shown to abnormally accumulate in thepost-mortem brain tissue of individuals diagnosed with ALS (Amyotrophic LateralSclerosis) and FTD (Frontal Temporal Dementia). This long-awaited conncectionbetween these two diseases provides an explanation for the observed clinical overlap. Alternate Names: anti-TARD binding protein antibody, anti-TAR DNA-binding protein 43 antibody,anti-TDP-43 antibody, anti-TDP43 antibody.
Gene ID 23435, 230908
UniProt Q13148
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines
Application Notes Suggested working dilutions: Western Blot 0.5 to 2.0 ug/ ml
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Tris-glycine, 150mM NaCl. Preservative: 0.05% sodium azide.
Preservative Sodium azide
Storage 4 °C
Neumann, Sampathu, Kwong et al.: "Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis." in: Science (New York, N.Y.), Vol. 314, Issue 5796, pp. 130-3, 2006 (PubMed).

Mackenzie, Bigio, Ince et al.: "Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations." in: Annals of neurology, Vol. 61, Issue 5, pp. 427-34, 2007 (PubMed).

Geser, Brandmeir, Kwong et al.: "Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis." in: Archives of neurology, Vol. 65, Issue 5, pp. 636-41, 2008 (PubMed).

Alternatives for antigen "TAR DNA Binding Protein (TARDBP)", type "Antibodies"
Hosts (88), (24), (6), (1)
Reactivities (115), (67), (48), (33), (18), (18), (17), (16), (5), (3), (1)
Applications (104), (50), (21), (20), (20), (19), (10), (3), (3), (1), (1)
Conjugates (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (18), (13), (9), (7), (7), (6), (3), (3), (2), (1), (1), (1)
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