TAR DNA Binding Protein (TARDBP) antibody

Antigen: TAR DNA Binding Protein (TARDBP)

Synonyms: ALS10, TDP-43, Tdp43, C85084, 1190002A23Rik, fb77f02, fc52g10, wu:fb77f02, wu:fc52g10, tardbp, MGC53141, TARDBP, TDP43, DKFZp459I2127, MGC129120

Clonality: Polyclonal

Host: Rabbit

Reactivity: Chicken, Human, Monkey, Mouse (Murine), Xenopus laevis, Zebrafish (Danio rerio)

Conjugate: Un-conjugated

Application: Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)

Catalog no.: ABIN188988

Additional Information

Alternative name: TARDBP

Gene ID: 23435

Immunogen: A synthetic peptide to a C-terminal region [within residues 350-414] of the humanTARDBP protein. [Swiss-Prot# Q13148].

Cross-Reactivity: Human

Description: HIV-1, the viral cause of acquired immunodeficiency syndrome (AIDS), contains an RNAgenome that produces a chromosomally integrated DNA during the replicative cycle.Activation of HIV-1 gene expression, by the transactivator Tat, is dependent on an RNAregulatory element (TAR) located downstream of the transcription initiation site.TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNAand represses HIV-1 transcription. In addition, this protein regulates alternate splicing ofthe CFTR gene. The resulting aberrant splicing is associated with pathological featurestypical of cystic fibrosis. As well, mutations in this gene are linked between ALS(Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia). Alternate Names: anti-TARD binding protein antibody, anti-TAR DNA-binding protein 43 antibody,anti-TDP-43 antibody, anti-TDP43 antibody.

Specificity: Species Reactivity: This antibody reacts with human protein. Localization: Nuclear.

Application Details

Application Notes: Suggested working dilutions: Western Blot 0.5 to 2.0 ug/ ml

Concentration: 1 mg/ml

Purification: Affinity Purified

Buffer: Tris-glycine, 150mM NaCl. Preservative: 0.05% sodium azide.

Storage: Store at 4C. Do not freeze.

Research Area: Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines

Restrictions: For Research Use only

Images

Detection of TARDBP in HeLa WCE using ABIN188986

Publications

Neumann, Sampathu, Kwong et al.: "Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis." in: Science (New York, N.Y.), Vol. 314, Issue 5796, pp. 130-3, 2006 (PubMed).

Geser, Brandmeir, Kwong et al.: "Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis." in: Archives of neurology, Vol. 65, Issue 5, pp. 636-41, 2008 (PubMed).