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Details for Product No. ABIN188988

TAR DNA Binding Protein (TARDBP) antibody

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Antigen
Synonyms ALS10, TDP-43, Tdp43, C85084, 1190002A23Rik, wu:fb77f02, wu:fc52g10, TARDBP, TDP43, DKFZp459I2127, tardbp
Reactivity
»Alternatives Chicken, Human, Monkey, Mouse (Murine), Xenopus laevis, Zebrafish (Danio rerio)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN188988
Quantity 25 µL
Price
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Immunogen A synthetic peptide to a C-terminal region [within residues 350-414] of the humanTARDBP protein. [Swiss-Prot# Q13148].
Specificity Species Reactivity: This antibody reacts with human protein. Localization: Nuclear.
Cross-Reactivity Human
Purification Affinity Purified
Alternative Name TARDBP
Background HIV-1, the viral cause of acquired immunodeficiency syndrome (AIDS), contains an RNAgenome that produces a chromosomally integrated DNA during the replicative cycle.Activation of HIV-1 gene expression, by the transactivator Tat, is dependent on an RNAregulatory element (TAR) located downstream of the transcription initiation site.TARDBP is a transcriptional repressor that binds to chromosomally integrated TAR DNAand represses HIV-1 transcription. In addition, this protein regulates alternate splicing ofthe CFTR gene. The resulting aberrant splicing is associated with pathological featurestypical of cystic fibrosis. As well, mutations in this gene are linked between ALS(Amyotrophic Lateral Sclerosis) and FTD (Frontal Temporal Dementia). Alternate Names: anti-TARD binding protein antibody, anti-TAR DNA-binding protein 43 antibody,anti-TDP-43 antibody, anti-TDP43 antibody.
Gene ID 23435
Research Area Chromatin and Nuclear Signaling, Transcription Factors, DNA/RNA, Hormones, Cytokines
Application Notes Suggested working dilutions: Western Blot 0.5 to 2.0 ug/ ml
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Tris-glycine, 150mM NaCl. Preservative: 0.05% sodium azide.
Preservative Sodium azide
Storage 4 °C
Neumann, Sampathu, Kwong et al.: "Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis." in: Science (New York, N.Y.), Vol. 314, Issue 5796, pp. 130-3, 2006 (PubMed).

Geser, Brandmeir, Kwong et al.: "Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis." in: Archives of neurology, Vol. 65, Issue 5, pp. 636-41, 2008 (PubMed).

Alternatives for antigen "TAR DNA Binding Protein (TARDBP)", type "Antibodies"
Hosts (88), (24), (6), (1)
Reactivities (115), (67), (48), (33), (18), (18), (17), (16), (5), (3), (1)
Applications (104), (50), (22), (21), (20), (20), (10), (3), (3), (1), (1)
Conjugates (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (18), (13), (9), (7), (7), (6), (3), (3), (2), (1), (1), (1)
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