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Details for Product No. ABIN189195

Calponin 1 (CNN1) antibody

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Antigen
Synonyms XclpH3, clpH3, cnn2, SMCC, Sm-Calp, CN, CnnI, MGC69240
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN189195
Quantity 0.1 mL
Price
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Immunogen Synthetic peptide corresponding to residues near the C-term of Calponin (Human).
Clone EP798Y
Isotype IgG
Specificity A synthetic peptide corresponding to residues near the C-term of human Calponin wasused as an immunogen. Species Reactivity: Reacts in Human, Mouse, and Rat. Not tested in other species. Localization: Cytoplasmic.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification Affinity Purified
Alternative Name Calponin-1
Background Calponin is a smooth muscle specific, actin-, tropomyosin- and calmodulin-bindingprotein thought to be involved in regulation of actomyosin as well as the regulation ormodulation of contraction (1). Calponin binds filamentous actin (F-actin) through twodistinct sites ABS1 and ABS2, with an affinity in the low micromolar range (2)Immunoreactivity for calponin, along with alpha-smooth muscle actin and smoothmuscle myosin heavy chains, confirms the known neoplastic myoepithelial componentof adenoid cystic carcinomas and epithelial-myoepithelial carcinomas. The consistentlypositive staining pattern in adenoid cystic carcinomas may be diagnostically useful indiscriminating histologically similar but consistently negative polymorphous low-gradeadenocarcinomas (3). Alternate Names: anti-Basic calponin antibody, anti-CNN 1 antibody, anti-CNN1 antibody, anti-Calponin 1antibody, anti-Calponin 1 basic smooth muscle antibody, anti-Calponin H1 smoothmuscle antibody, anti-Calponin1 antibody, anti-Calponins basic antibody, anti-SMCCantibody, anti-Sm Calp antibody.
Gene ID 1264, 12797, 65204
UniProt P51911
Application Notes Suggested working dilutions: immunohistochemistry 1:100 to 250 ,Western Blot 1:20,Immunocytochemistry 1:100 to 250
Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. Preservative: 0.01% sodium azide.
Preservative Sodium azide
Storage -20 °C
Strasser, Gimona, Moessler et al.: "Mammalian calponin. Identification and expression of genetic variants." in: FEBS letters, Vol. 330, Issue 1, pp. 13-8, 1993 (PubMed).

Jeyasuria, Wetzel, Bradley et al.: "Progesterone-regulated caspase 3 action in the mouse may play a role in uterine quiescence during pregnancy through fragmentation of uterine myocyte contractile proteins." in: Biology of reproduction, Vol. 80, Issue 5, pp. 928-34, 2009 (PubMed).

Alternatives for antigen "Calponin 1 (CNN1)", type "Antibodies"
Hosts (43), (12), (1)
Reactivities (54), (24), (20), (17), (14), (14), (14), (1), (1), (1), (1)
Applications (32), (30), (17), (12), (10), (6), (5), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (2), (2), (2), (1), (1), (1)
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