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Details for Product No. ABIN189382

Cytohesin 3 (CYTH3) antibody

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Antigen
Synonyms GRP1, ARNO3, PSCD3, AI648983, CLM3, Grp1, Pscd3, Sec7, Sec7C, CYTH3, pscd3, MGC145373
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Monoclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN189382
Quantity 0.1 mL
Price
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Immunogen A synthetic peptide corresponding to residues near the SEC7 domain of GRP1 was used as immunogen.
Clone EP394Y
Isotype IgG
Specificity A synthetic peptide corresponding to residues near the SEC7 domain of GRP1 wasused as immunogen. Species Reactivity: Cross reacts with Human, Mouse and Rat.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification Aff - Purified
Alternative Name Cytohesin 3
Background GRP1 (general receptor for 3-phosphoinositides) is composed of an N-terminal heptadrepeat, an Arf exchange domain with homology to the yeast Sec7 protein, a PH domain,and a C-terminal polybasic region (1). The PH domain of GRP1 binds PtdIns(3, 4, 5)P3with high affinity, but not PtdIns(3, 4)P2 or PtdIns(3)P, potentially making it a target forPI-3-kinase. Furthermore, GRP1 acts as a nucleotide exchange factor for the small GTPproteins of the ARF family (2). While GRP1 catalyses guanine-nucleotide exchangespecifically on ARF5, other GRP1 homologues (ARNO and cytohesin-1) will onlyfunction on ARF6 and ARF3 respectively (3). Alternate Names: anti-GRASP antibody, anti-GRP1 associated scaffold protein antibody.
Gene ID 9265, 56149, 192254
UniProt O43739
Research Area Signaling
Application Notes Suggested working dilutions: Western Blot 1:500
Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. Preservative: 0.01% sodium azide.
Preservative Sodium azide
Storage -20 °C
Klarlund, Guilherme, Holik et al.: "Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains." in: Science (New York, N.Y.), Vol. 275, Issue 5308, pp. 1927-30, 1997 (PubMed).

Klarlund, Rameh, Cantley et al.: "Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate." in: The Journal of biological chemistry, Vol. 273, Issue 4, pp. 1859-62, 1998 (PubMed).

Alternatives for antigen "Cytohesin 3 (CYTH3)", type "Antibodies"
Hosts (16), (5)
Reactivities (21), (13), (10)
Applications (20), (12), (5), (2), (1), (1), (1), (1), (1)
Epitopes (8), (4), (1), (1), (1)
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