Cytohesin 3 (CYTH3) antibody

Details for Product No. ABIN189382
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Antigen
Synonyms GRP1, ARNO3, PSCD3, AI648983, CLM3, Grp1, Pscd3, Sec7, Sec7C, CYTH3, pscd3, MGC145373
Reactivity
Human
(21), (10), (8)
Host
Rabbit
(16), (5)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(20), (11), (4), (1), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN189382
Quantity 0.1 mL
Price
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Immunogen A synthetic peptide corresponding to residues near the SEC7 domain of GRP1 was used as immunogen.
Clone EP394Y
Isotype IgG
Specificity A synthetic peptide corresponding to residues near the SEC7 domain of GRP1 wasused as immunogen. Species Reactivity: Cross reacts with Human, Mouse and Rat.
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Purification Aff - Purified
Alternative Name Cytohesin 3
Background GRP1 (general receptor for 3-phosphoinositides) is composed of an N-terminal heptadrepeat, an Arf exchange domain with homology to the yeast Sec7 protein, a PH domain,and a C-terminal polybasic region (1). The PH domain of GRP1 binds PtdIns(3, 4, 5)P3with high affinity, but not PtdIns(3, 4)P2 or PtdIns(3)P, potentially making it a target forPI-3-kinase. Furthermore, GRP1 acts as a nucleotide exchange factor for the small GTPproteins of the ARF family (2). While GRP1 catalyses guanine-nucleotide exchangespecifically on ARF5, other GRP1 homologues (ARNO and cytohesin-1) will onlyfunction on ARF6 and ARF3 respectively (3). Alternate Names: anti-GRASP antibody, anti-GRP1 associated scaffold protein antibody.
Gene ID 9265, 56149, 192254
UniProt O43739
Research Area Signaling
Application Notes Suggested working dilutions: Western Blot 1:500
Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. Preservative: 0.01% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Cytohesin 3 (CYTH3) antibody Western blot analysis on Hunan brain lysate using anti-GRP1 RabMAb (cat. # 110-57015), dilution 1:500.
General Klarlund, Guilherme, Holik et al.: "Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains." in: Science (New York, N.Y.), Vol. 275, Issue 5308, pp. 1927-30, 1997 (PubMed).

Klarlund, Rameh, Cantley et al.: "Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate." in: The Journal of biological chemistry, Vol. 273, Issue 4, pp. 1859-62, 1998 (PubMed).

Hosts (16), (5)
Reactivities (21), (10), (8)
Applications (20), (11), (4), (1), (1), (1), (1)
Epitopes (6), (4), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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