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Details for Product No. ABIN189464

Telomeric Repeat Binding Factor 2 (TERF2) antibody

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Antigen
Synonyms TRF2, TRBF2, trf2, TERF2
Reactivity
»Alternatives Hamster, Human, Monkey, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN189464
Quantity 0.1 mL
Price
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Immunogen Baculovirus purified TRF2 protein.
Specificity Species Reactivity: Human. Localization: Nuclear.
Cross-Reactivity Human
Purification Purified
Alternative Name TERF2
Background TRF2 is a ubiquitously expressed protein that is implicated in the control of telomerelength. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplexTTAGGG repeats and is localized to all human telomeres in metaphase chromosomes.TRF2 is thought to protect chromosome ends by maintaining the correct structure attelomere termini. The use of mutant forms of TRF2 has implied a role for TRF2 in theprevention of senescence in primary human cells. Recently, it has been shown thatinhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF2 isoverexpressed in a number of human tumors and overexpression of TRF2 may beoncogenic. Alternate Names: anti-Telomeric DNA binding protein antibody, anti-Telomeric repeat binding factor 2antibody, anti-Telomeric repeat binding protein 2 antibody, anti-TERF 2 antibody,anti-TERF2 antibody, anti-TRBF 2 antibody, anti-TRBF2 antibody, anti-TRF 2 antibody,anti-TTAGGG repeat binding factor 2 antibody.
Gene ID 7014
Research Area DNA/RNA, Cell Cycle, Enzymes
Application Notes Suggested working dilutions: chromatin Western Blot 1:2000-1:5,000. Positive Controls: HeLa nuclear extract and HeLa whole cell lysate.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/ml
Buffer Tris-glycine, 150mM NaCl, 0.1% BSA. Preservative: 0.05% sodium azide.
Preservative Sodium azide
Storage 4 °C
Smogorzewska, van Steensel, Bianchi et al.: "Control of human telomere length by TRF1 and TRF2." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1659-68, 2000 (PubMed).

Zhu, Kuester, Mann et al.: "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres." in: Nature genetics, Vol. 25, Issue 3, pp. 347-52, 2000 (PubMed).

Smith, de Lange: "Tankyrase promotes telomere elongation in human cells." in: Current biology : CB, Vol. 10, Issue 20, pp. 1299-302, 2001 (PubMed).

Smogorzewska, de Lange: "Different telomere damage signaling pathways in human and mouse cells." in: The EMBO journal, Vol. 21, Issue 16, pp. 4338-48, 2002 (PubMed).

Alternatives for antigen "Telomeric Repeat Binding Factor 2 (TERF2)", type "Antibodies"
Hosts (25), (11), (11)
Reactivities (44), (14), (8), (2), (2), (1), (1), (1), (1)
Applications (42), (20), (17), (14), (11), (11), (10), (4), (3), (3), (3), (1), (1), (1)
Conjugates (2), (2), (2), (1), (1)
Epitopes (6), (2), (1), (1), (1), (1), (1), (1), (1)
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