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Details for Product No. ABIN189510

Melan A (MLANA) antibody

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Synonyms MART1, MART-1
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN189510
Quantity 0.1 mL
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Clone EP1422Y
Isotype IgG
Specificity A synthetic peptide corresponding to residues on the N-terminus of human MART-1 wasused as an immungen. Species Reactivity: Cross reacts in Human. Does not react in Mouse or Rat.
Cross-Reactivity Human
Purification Affinity Purified
Alternative Name MART-1
Background MART-1 has been widely studied as a melanoma-specific antigen and as amelanosome-specific marker. A role for MART-1 in pigmentation is expected becauseits expression pattern and subcellular distribution is quite similar to the othermelanosomal proteins and usually correlates with melanin content. MART-1 forms acomplex with Pmel17 and affects its expression, stability, trafficking, and the processingwhich is required for melanosome structure and maturation. MART-1 is indispensablefor Pmel17 function and thus plays an important role in regulating mammalianpigmentation (1). A gene has been identified that encodes a melanocyte lineage-specificprotein (MART-1, melanoma antigen recognized by T cells 1) that is a widely sharedmelanoma antigen recognized by the T lymphocytes of patients with establishedmalignancy. Identification of this gene opens possibilities for the development ofimmunotherapies for patients with melanoma (2). Alternate Names: anti-Antigen LB39 AA antibody, anti-Antigen SK29 AA antibody, anti-MART 1 antibody,anti-MART1 antibody, anti-Melan A antibody, anti-Melan A protein antibody,anti-Melanoma antigen recognized by T cells 1 antibody, anti-MLAN A antibody,anti-MLANA antibody.
Gene ID 2315, 77836, 293890
UniProt Q16655
Research Area Cancer
Application Notes Suggested working dilutions: immunohistochemistry 1:100-250,Western Blot 1:1000
Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. Preservative: 0.01% sodium azide.
Preservative Sodium azide
Storage -20 °C
Kawakami, Eliyahu, Delgado et al.: "Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 9, pp. 3515-9, 1994 (PubMed).

Hoashi, Watabe, Muller et al.: "MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes." in: The Journal of biological chemistry, Vol. 280, Issue 14, pp. 14006-16, 2005 (PubMed).

Massoumi, Kuphal, Hellerbrand et al.: "Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma." in: The Journal of experimental medicine, Vol. 206, Issue 1, pp. 221-32, 2009 (PubMed).

Alternatives for antigen "Melan A (MLANA)", type "Antibodies"
Hosts (48), (39)
Reactivities (81), (1), (1), (1)
Applications (55), (35), (18), (15), (11), (10), (8), (8), (7), (6), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (2), (1), (1), (1), (1), (1), (1), (1), (1)