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Details for Product No. ABIN189672

PI3 Kinase P85 alpha (C-Term) antibody

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Synonyms PI3KA, AGM7, GRB1, p85, p85-ALPHA, PI3K
»Alternatives C-Term
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN189672
Quantity 0.1 mL
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Clone EP380Y
Isotype IgG
Specificity A synthetic peptide corresponding to residues in the C-term of human PI3-K 85 alphawas used as an immunogen. Species Reactivity: Cross reacts in Human and Rat. Does not react in Mouse.
Cross-Reactivity Human, Rat (Rattus)
Purification Aff - Purified
Alternative Name PIK3R1 / GRB1
Background PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signaltransduction. PI3-K consists of two subunits, the regulatory subunit p85 and the catalyticsubunit p110 (1-2). In quiescent cells p85 maintains p110 in a low activity state. Upongrowth factor stimulation, p85 directly interacts with phosphotyrosine residues ofactivated growth factor receptors or adaptor proteins leading to activation of p110. p85exists in two isoforms: p85, including two short forms termed p50 and p55/AS53 andp85 including short form p55PIK/p55 (3). The p85 adaptor protein uses the inter-SH2(iSH2) region to bind p110 and employs SH3 and SH2 domains, phosphotyrosineresidues, and proline-rich motifs to interact with activated tyrosine kinases such asBCR/ABL and NPM/ALK or adaptor proteins including Shc, c-Cbl, Crk-L, and Gab2(4-5). Alternate Names: anti-GRB1 antibody, anti-p50 alpha antibody, anti-p55 alpha antibody, anti-p85 alphaantibody, anti-Phosphatidylinositol 3 kinase associated p85 alpha antibody,anti-Phosphatidylinositol 3 kinase regulatory 1 antibody, anti-Phosphatidylinositol 3kinase regulatory alpha subunit antibody, anti-Phosphatidylinositol 3 kinase regulatorysubunit alpha antibody, anti-Phosphatidylinositol 3 kinase regulatory subunit polypeptide1 antibody, anti-Phosphoinositide 3 kinase regulatory subunit 1 antibody,anti-Phosphoinositide 3 kinase regulatory subunit polypeptide 1 (p85 alpha) antibody,anti-PI3 kinase p85 alpha subunit antibody, anti-PI3 kinase p85 subunit alpha antibody,anti-PI3K antibody, anti-PIK3R1 antibody, anti-PtdIns 3 kinase p85 alpha antibody.
Gene ID 5295, 18708, 25513
UniProt P27986
Application Notes Suggested working dilutions: flow cytometry / FACS analysis 1:60,immunohistochemistry 1:100-250,immunoprecipitation 1:50,Western Blot 1:500-2000,Immunocytochemistry 1:250-500
Restrictions For Research Use only
Format Liquid
Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, and 0.05% BSA. Preservative: 0.01% sodium azide.
Preservative Sodium azide
Storage -20 °C
Jain, Langdon, Varticovski: "Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase." in: Oncogene, Vol. 14, Issue 18, pp. 2217-28, 1997 (PubMed).

Alternatives for antigen "PI3 Kinase P85 alpha", type "Antibodies"
Hosts (105), (29)
Reactivities (124), (85), (81), (42), (36), (36), (12), (2), (1)
Applications (95), (45), (30), (29), (24), (18), (9), (9), (5), (3), (3), (2), (2), (2), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (19), (14), (13), (13), (7), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)