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Details for Product No. ABIN189747

MLX Interacting Protein-Like (MLXIPL) antibody

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Antigen
Synonyms ChREBP, WS-bHLH, Wbscr14, bHLHd14, MIO, CHREBP, MONDOB, WBSCR14, MLXIPL
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN189747
Quantity 25 µL
Price
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Immunogen An C-terminal synthetic peptide made to the human ChREBP protein sequence(between residues 800-852).
Specificity This antibody is specific for ChREBP. Species Reactivity: This antibody reacts with human, mouse (see Dentin et al) and rat ChREBP. There is83% homology of the immunogen with the mouse ChREBP protein. Other species havenot been tested. Localization: Nuclear.
Cross-Reactivity Human, Rat (Rattus)
Purification Purified
Alternative Name MLXIPL
Background ChREBP is a transcription factor involved in activating genes that encode enzymes offatty acid biosynthesis in liver and adipose. This protein may have relevance to lipidmetabolism, obesity, and type II diabetes. Alternate Names: anti-WBSCR14 antibody, anti-Williams Beuren Syndrome Chromosome Region 14antibody, anti-MIO antibody, anti-MONDOB antibody, anti-WS-bHLH antibody. Related Diseases: Williams-Beuren syndrome, Cancer
Gene ID 51085
Application Notes Suggested working dilutions: chromatin immunofluorescence 1:100-1:500,Western Blot 1/200
Restrictions For Research Use only
Format Liquid
Concentration 1.1 mg/ml
Buffer Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage 4 °C
Xu, Christian, Jump: "Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist." in: The Journal of biological chemistry, Vol. 281, Issue 27, pp. 18351-62, 2006 (PubMed).

Wang, Botolin, Xu et al.: "Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity." in: Journal of lipid research, Vol. 47, Issue 9, pp. 2028-41, 2006 (PubMed).

Dentin, Benhamed, Hainault et al.: "Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice." in: Diabetes, Vol. 55, Issue 8, pp. 2159-70, 2006 (PubMed).

Erhuma, Salter, Sculley et al.: "Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat." in: American journal of physiology. Endocrinology and metabolism, Vol. 292, Issue 6, pp. E1702-14, 2007 (PubMed).

Alternatives for antigen "MLX Interacting Protein-Like (MLXIPL)", type "Antibodies"
Hosts (53), (1)
Reactivities (51), (27), (24), (13), (13), (12), (12)
Applications (32), (30), (20), (10), (10), (7), (5), (5), (5)
Conjugates (6), (6), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (14), (11), (7), (7), (3), (2), (2), (1), (1)
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