Disrupted in Schizophrenia 1 (DISC1) (Internal Region) antibody

Details for Product No. ABIN190904
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Antigen
Synonyms DISC1, C1orf136, SCZD9
Epitope
Internal Region
(34), (33), (17), (7), (6), (6), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(109), (47), (15)
Host
Goat
(111), (7), (5), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Methode Type Peptide ELISA
Application
ELISA, Western Blotting (WB)
(103), (50), (34), (25), (20), (11), (6), (3), (3)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN190904
374.27 $
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Immunogen Peptide with sequence C-HSEDKRKTPLKVLE, from the internal region of the protein sequence according to NP_001012975.1, NP_061132.2.
Specificity This antibody is expected to recognise isoforms L ( NP_061132.2) and Lv (NP_001012975.1) only.
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name DISC1
Background Synonyms: DISC1, disrupted in schizophrenia 1, RP4-730B13.1, KIAA0457
Gene ID 27185
NCBI Accession NP_061132, NP_001012975
Research Area Neurology, Alzheimer's Disease
Application Notes ELISA: antibody detection limit dilution 1:128000.
Western blot: Approx 100 kDa band observed in human brain (cerebellum, hippocampus and frontal cortex) lysates (calculated MW of 93.6 kDa according to NP_001012975.1). Recommended concentration: 0.1-0.3 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
anti-Disrupted in Schizophrenia 1 (DISC1) (Internal Region) antibody ABIN190904 (0.1µg/ml) staining of human brain (hippocampus) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
General Millar, Pickard, Mackie et al.: "DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling." in: Science (New York, N.Y.), Vol. 310, Issue 5751, pp. 1187-91, 2005 (PubMed).

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