Fibrinogen (Oxidized), (Total Fraction) antibody

Antigen: Fibrinogen (Oxidized), (Total Fraction)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA)

Catalog no.: ABIN191679

Additional Information

Characteristics: Synonyms: FGA, FGB, FGG, Fibrinogen alpha chain, Fibrinogen beta chain, Fibrinogen gamma chain

Immunogen: Human oxidized Fibrinogen (total fraction)

Cross-Reactivity: Human

Description: Fibrinogen is the main protein of blood coagulation system. It is a large protein and itconsists of two identical subunits that contain three polypeptide chains: alpha, beta andgamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released bythrombin from the N terminal parts of alpha and beta chains, respectively. In this wayfibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses ofarteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogenactivation is also involved in pathogenesis of inflammation, tumor growth and many otherdiseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level offibrinogen in patient's blood is regarded as an independent risk factor for cardiovasculardiseases. An increase in blood fibrinogen concentration was shown to be a strongpredictor of coronary heart disease (Sonel A. et al, and Rapold H. J. et al). All these factsmake fibrinogen an important parameter in the diagnosis of cardiovascular diseases.

Specificity: This antibody detects Fibrinogen, Cu2+ LDL, MDA-LDL, HOCl LDL There were no crossreactivities obtained with other oxidized proteins like MDA-HAS, MDA-HDL, HOCl-HAS,HOCl-HDL. Species: Human. Others not tested.

Application Details

Application Notes: ELISA and related methods (1: 5000 - 1: 250.000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Serum

Storage: Store lyophilized at 2 - 8 °C and reconstituted at -20 °C. Avoid repeated freezing andthawing. Shelf life: One year from despatch.

Research Area: Extracellular Matrix

Restrictions: For Research Use only