Apolipoprotein(a) / LP(a) (Oxidized) antibody

Antigen: Apolipoprotein(a) / LP(a) (Oxidized)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Catalog no.: ABIN191721

Additional Information

Characteristics: Synonyms: Apo(a), LPA

Swiss-Prot: P08519

Immunogen: Human autooxidized Lipoprotein (a)Genename: LPA

Cross-Reactivity: Human

Description: Lipoprotein (a) (Lp(a)) is a lipoprotein subclass assembled in the blood from low densitylipoprotein (LDL) molecules and apolipoprotein-a (apo-a). Lp(a) recruits inflammatory cellsthrough interaction with Mac-1 integrin. High Lp(a) in blood is a risk factor for coronaryheart disease, cerebrovascular disease, atherosclerosis, thrombosis, and stroke. Lp(a)concentrations may be affected by disease states, but are only moderately affected by diet,exercise and other environmental factors. Lipid-reducing drugs have no effect on Lp(a)concentration. High Lp(a) predicts risk of early atherosclerosis similar to high LDL, but inadvanced atherosclerosis, Lp(a) is a risk factor independent of LDL, indicating a coagulantrisk of plaque thrombosis. Apo(a) contains domains that are very similar to plasminogen(PLG). Lp(a) accumulates in the vessel wall and inhibits binding of PLG to the cell surface,reducing plasmin generation which increases clotting. This inhibition also promotesproliferation of smooth muscle cells. These unique features of Lp(a) suggest a role in thegeneration of clots and atherosclerosis.

Specificity: Fully oxidized modifications of LDL: Cu2+ oxidized LDL, MDA-LDL, HOCl-LDL, MDA-HSA,HOCl-HSA, HOCl-HDL. Native or minimally oxidized LDLSpecies: Human. Others not tested. Add. Information: LocusID 4018

Application Details

Application Notes: ELISA and related methods (1/500-1/5.000). Immunohistochemistry on Paraffin Sections (< 1/500). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Serum

Storage: Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.

Restrictions: For Research Use only