Cyclic GMP (cGMP) antibody

Antigen: Cyclic GMP (cGMP)

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Radioimmunoassay (RIA)

Catalog no.: ABIN191762

Additional Information

Characteristics: Synonyms: cGMP, cyclic guanosine monophosphate

Alternative name: Cyclic GMP

Immunogen: Synthetic human cGMP, poly Lysin conjugated

Cross-Reactivity: Human

Description: Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a mannersimilar to that observed with cAMP. Peptide hormones, such as the natriuretic factors,activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) alsostimulates cGMP production by activating soluble GC, perhaps by binding to the hememoiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effectsthrough the activation of specific cGMP dependent protein kinases (PKG).

Specificity: This antibody detects Synthetic cGMP, no cross-reactivity with cAMP. Species: Human. Others not tested.

Application Details

Application Notes: RIA (1: 800). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Serum

Storage: Store lyophilized at 2 - 8 °C and reconstituted at -20 °C. Avoid repeated freezing andthawing. Shelf life: One year from despatch.

Restrictions: For Research Use only