Cyclic AMP antibody

Antigen: Cyclic AMP

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Radioimmunoassay (RIA)

Catalog no.: ABIN191764

Additional Information

Characteristics: Synonyms: cAMP, Cyclic Adenosine Monophosphate

Immunogen: Synthetic human succinylated cAMP, BSA conjugated.

Cross-Reactivity: Human

Description: Cyclic adenosine monophosphate (cAMP) plays a key role as an intracellular secondmessenger for transduction events that follow a number of extracellular signals. TheG-Protein Coupled Receptors (GPCR) is the largest family of cell surface receptors. They canbe activated by different ligands, such as neurotransmitters, hormones, ions, smallmolecules, peptides, and other physiological signaling molecules. Typically, the binding ofthe ligands to its receptor resulting in the activation of G-proteins, in return, activates theeffector adenylyl cyclase evoking the production of cAMP. The activation of a proteinkinase by cAMP results in the phosphorylation of substrate proteins. Currently successfuldrugs in marketing have been developed to target these receptors. Among the GPCRs,~367 receptors are potential drug development targets, but only about 20 have been usedto generate therapeutically and commercially successful drugs so far. Because theinvolvement of cAMP can amplify the response of the ligand binding, the secondmessenger cAMP has been largely employed to monitor the activation of the GPCR tofacilitate the therapeutic drug discovery.

Specificity: This antibody detects Synthetic Succinylated cAMP. Species: Human. Others not tested.

Application Details

Application Notes: RIA (1/1000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Serum

Storage: Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.

Restrictions: For Research Use only