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CD34 (CD34) antibody (PE-Dyomics 647)

Antigen

CD34 (CD34)
Clonality Monoclonal (4H11[APG])
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives PE-Dyomics 647
Application
Alternatives Flow Cytometry (FACS)
1 reference available
Catalog no. ABIN192212
Quantity 100 tests
Price 416.00 $   Plus shipping costs $35.00
Shipping to
Availability Ships within 3 to 5 Business Days

Additional Information
Application Details Publications Alternatives back to top

Alternative name CD34
Immunogen Permanent human cell line derived from peripheral leucocytes of a patient suffering fromchronic myeloid leukaemia.
Isotype IgG1
Clone 4H11[APG]
Description CD34 is a highly glycosylated monomeric 111-115 kDa surface protein, which is present onmany stem cell populations. It is a well established stem cell marker, though its expressionon human hematopoietic stem cells is reversible. CD34 probably serves as a surfacereceptor that undergoes receptor-mediated endocytosis and regulates adhesion,differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34expression is likely to represent a specific state of hematopoietic development that mayhave altered adhering properties with expanding and differentiating capabilities in both invitro and in vivo conditions.
Specificity The antibody 4H11[APG] reacts with Class III epitope on CD34 (Mucosialin), a 110-115 kDamonomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitorscells and on the most pluripotential stem cells, it is gradually lost on progenitor cells. Theantibody 4H11[APG] completely blocks binding of Class II antibody QBEnd10 and Class IIIantibodies BIRMA K3 and 8G12 on KG1a cell line.HLDA VI, WS Code M MA58

Application Details
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Application Notes The reagent is designed for Flow Cytometry analysis of human blood cells using 20 µl reagent / 100 µl of whole blood or 10 6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azideand 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Storage Store in the dark at 2-8 o C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.Short-term exposure to room temperature should not affect the quality of the reagent.However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.
Research Area Hematopoietic Progenitors, Hematopoietic Stem Cells, Cardiogenesis, Lineage Markers, CD Antigens, Surface Receptors of Immune Cells
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Publications Elknerovua, Lacinovua, Soucek et al.: "Growth inhibitory effect of the antibody to hematopoietic stem cell antigen CD34 in leukemic cell lines." in: Neoplasma, Vol. 54, Issue 4, pp. 311-20, 2007 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "CD34 (CD34)", type "Antibodies"
Hosts Mouse (139), Rabbit (55), Rat (51), Chicken (1)
Reactivities Human (177), Mouse (Murine) (86), Rat (Rattus) (33), Dog (Canine) (27), Cow (Bovine) (15), Pig (Porcine) (15), Rabbit (15), Monkey (6), Primate (5), Primates (3), Rhesus Monkey (2)
Applications Flow Cytometry (FACS) (186), Western Blotting (WB) (86), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (54), Immunofluorescence (IF) (53), Immunoprecipitation (IP) (42), Immunohistochemistry (Frozen Sections) (IHC (fro)) (37), ELISA (28), Immunohistochemistry (IHC) (13), Immunocytochemistry (ICC) (11), Enzyme Immunoassay (EIA) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (4), Functional Studies (Func) (3), Immunoelectron Microscopy (IEM) (2), Dot Blot (Dot) (1)
Conjugates FITC (34), PE (25), Biotin (16), APC (8), RPE (6), Alexa Fluor 488 (3), Alexa Flour 488 (2), Alexa Fluor 350 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), Cy3 (2), Cy5 (2), Cy5,PE (2), Cy5.5 (2), Cy7 (2), Cy7,PE (2), Gold (2), HRP (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy5.5 (2), PE,Cy7 (2), RBITC (2), Alexa Fluor 700 (1), Cy5.5,PE (1), PE,DY647 (1), Pacific Blue (1)
Epitopes pTyr330 (1)