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Details for Product No. ABIN192276

CD4 Molecule (CD4) (N-Term) antibody (PE,DyLight 594)

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Antigen
Synonyms CD4mut, p55, W3/25, L3T4, Ly-4, cd4
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives PE,DyLight 594
Application
»Alternatives Flow Cytometry (FACS), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN192276
Quantity 100 tests
Price
464.64 $   Plus shipping costs $45.00
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Availability Will be delivered in 4 to 5 Business Days
Immunogen 2 N-terminal domains of human CD4 fused to human IgG1 Fc
Clone MEM-241
Isotype IgG1
Specificity The antibody MEM-241 recognizes CD4 antigen, a 55 kDa transmebrane glycoproteinexpressed on a subset of T lymphocytes (helper T-cells) and also on monocytes, tissuemacrophages and granulocytes.HCDM (former HLDA VIII) Meeting, May 2006, Québec, Canada, WS Code M241
Alternative Name CD4
Background CD4 is a single chain transmembrane glycoprotein and belongs to immunoglobulinsupergene family. In extracellular region there are 4 immunoglobulin-like domains (1 Ig-likeV-type and 3 Ig-like C2-type). Transmembrane region forms 25 aa, cytoplasmic tail consistsof 38 aa. Domains 1,2 and 4 are stabilized by disulfide bonds. The intracellular domain ofCD4 is associated with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4segregates into specific detergent-resistant T-cell membrane microdomains.Extracellular ligands: MHC class II molecules (binds to CDR2-like region in CD4 domain 1),HIV envelope protein gp120 (binds to CDR2-like region in CD4 domain 1), IL-16 (binds toCD4 domain 3), Human seminal plasma glycoprotein gp17 (binds to CD4 domain 1),L-selectinIntracellular ligands: p56LckCD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHCclass II molecules) and HIV infection (human immunodeficiency virus, CD4 is primaryreceptor for HIV-1 surface glycoprotein gp120). CD4 regulates T-cell activation, T/B-celladhesion, T-cell diferentiation, T-cell selection and signal transduction. Defects in antigenpresentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost completeabsence in patients blood, tissue and organs (SCID immunodeficiency).
Research Area Immunology, Adaptive Immunity, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells
Application Notes The reagent is designed for Flow Cytometry analysis of human blood cells using 20 µl reagent / 100 µl of whole blood or 10 6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Restrictions For Research Use only
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azideand 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Preservative Sodium azide
Storage 4 °C
Product cited in: Zola, Swart, Banham et al.: "CD molecules 2006--human cell differentiation molecules." in: Journal of immunological methods, Vol. 319, Issue 1-2, pp. 1-5, 2007 (PubMed).

Manasa, Musabaike, Masimirembwa et al.: "Evaluation of the Partec flow cytometer against the BD FACSCalibur system for monitoring immune responses of human immunodeficiency virus-infected patients in Zimbabwe." in: Clinical and vaccine immunology : CVI, Vol. 14, Issue 3, pp. 293-8, 2007 (PubMed).

Anderson, Sayers, Haniffa et al.: "Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells." in: Journal of leukocyte biology, Vol. 84, Issue 1, pp. 124-33, 2008 (PubMed).

Karlsson, Cowley, Martinez et al.: "Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3." in: Experimental hematology, Vol. 36, Issue 9, pp. 1167-75, 2008 (PubMed).

Alternatives for antigen "CD4 Molecule (CD4)", type "Antibodies"
Hosts (741), (399), (142), (3), (1)
Reactivities (619), (459), (150), (53), (37), (34), (31), (27), (22), (21), (14), (8), (5), (5), (4), (3), (2), (1), (1), (1)
Applications (992), (204), (165), (152), (129), (118), (116), (62), (52), (51), (33), (30), (11), (5), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Conjugates (186), (132), (124), (69), (31), (18), (9), (8), (7), (6), (6), (6), (6), (6), (6), (6), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (37), (11), (10), (9), (8), (5), (5), (5), (4), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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