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HLA-DR-gamma (CD74) antibody

Antigen

HLA-DR-gamma (CD74)
Synonyms DHLAG, HLADG, Ia-GAMMA, Ii, CLIP
Clonality Monoclonal (LN2)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Application
Alternatives Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Catalog no. ABIN192403
Quantity 0.1 mg  (1 mg/ml)  (Variants)
Price 260.00 $   Plus shipping costs $35.00
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Additional Information
Application Details Alternatives Secondary Antibodies Variants back to top

Alternative name CD74
Immunogen SU-DHL-4 lymphoma cells
Format Purified
Isotype IgG1  (Matching secondary antibodies)
Clone LN2
Description CD74 (the MHC II-associated invariant chain, Ii) is an type II transmembrane proteinexpressed in antigen-presenting cells, that serves as MHC II chaperone which promotesMHC II trafficking from the ER to endocytic compartments, prevents peptide binding in theER and contributes to peptide editing in the MHC II compartment, it is also an accessorysignaling molecule implicated e.g. in malignant B cell proliferation. Stimulation of cell surfaceCD74 leads to NFkappaB activation, which enables entry of the stimulated cell into the Sphase. CD74 binds pro-inflammatory cytokine MIF with high affinity and interacts with CD44.Binding of Vpu, an HIV1 protein, to CD74 modulates MHC II presentation.
Specificity The antibody LN2 is specific to CD74. It also reacts with activated neoplastic cells in T celllymphomas, lymph node germinal center, mantle zone B cells, histiocytes, interdigitatingreticulum cells, Langerhans cells, thymic dendritic cells and peripheral blood B lymphocytes.HLDA IV, WS Code B 129HLDA V, WS Code B CD74.3

Application Details
Alternatives Secondary Antibodies Variants back to top

Application Notes Immunohistochemistry (paraffin sections) - Recommended dilution: 10 µg/ml
Concentration 1 mg/ml
Purity > 95% (by SDS-PAGE)
Purification Purified from hybridoma culture supernatant by protein-A affinity chromatography.
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Storage Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.
Research Area Immunology, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells, Major Histocompatibility Complex (MHC)
Restrictions For Research Use only

Alternatives
Application Details Secondary Antibodies Variants back to top

Alternatives for antigen "HLA-DR-gamma (CD74)", type "Antibodies"
Hosts Mouse (82), Rabbit (23), Rat (8)
Reactivities Human (110), Rat (Rattus) (21), Mouse (Murine) (20), Pig (Porcine) (18), Cow (Bovine) (17), Horse (Equine) (17), Dog (Canine) (16), Sheep (Ovine) (15), Baboon (2), Rabbit (2), Chicken (1)
Applications Flow Cytometry (FACS) (85), Immunoprecipitation (IP) (37), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (28), Immunofluorescence (IF) (26), Western Blotting (WB) (26), Immunohistochemistry (Frozen Sections) (IHC (fro)) (14), Immunohistochemistry (IHC) (8), Immunocytochemistry (ICC) (5), ELISA (3), Enzyme Immunoassay (EIA) (2), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), ELISA (Detection) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates FITC (12), PE (8), Biotin (7), APC (4), Alexa Fluor 488 (2), Alexa Fluor 700 (2), Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), HRP (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), Pacific Blue (1), PerCP (1), RBITC (1), RPE (1)