Presenilin 2 antibody (N-Term)

Catalog No. ABIN1944732

Product Details anti-Presenilin 2 Antibody

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Binding Specificity: AA 32-65, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PSEN2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-65 amino acids from the N-terminal region of human PSEN2(Presenilin-2 NTF subunit).

Clone: RB30801

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Presenilin 2 antibody (ABIN1944732)

Levy-Lahad, Poorkaj, Wang, Fu, Oshima, Mulligan, Schellenberg: "Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene." in: Genomics, Vol. 34, Issue 2, pp. 198-204, (1997) (PubMed).

Li, Ma, Potter: "Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 26, pp. 12180-4, (1996) (PubMed).

Levy-Lahad, Wasco, Poorkaj, Romano, Oshima, Pettingell, Yu, Jondro, Schmidt, Wang: "Candidate gene for the chromosome 1 familial Alzheimer's disease locus." in: Science (New York, N.Y.), Vol. 269, Issue 5226, pp. 973-7, (1995) (PubMed).

Rogaev, Sherrington, Rogaeva, Levesque, Ikeda, Liang, Chi, Lin, Holman, Tsuda: "Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene." in: Nature, Vol. 376, Issue 6543, pp. 775-8, (1995) (PubMed).

Target Details for Presenilin 2

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Alternative Name: PSEN2 (PSEN2 Products)

Synonyms: AD3L antibody, AD4 antibody, CMD1V antibody, PS2 antibody, STM2 antibody, ALG-3 antibody, Ad4h antibody, Alg3 antibody, PS-2 antibody, Psnl2 antibody, pre2 antibody, zf-PS2 antibody, PSNL2 antibody, PSEN2 antibody, ad4 antibody, ps2 antibody, ad3l antibody, stm2 antibody, Ps2 antibody, presenilin 2 antibody, presenilin 2 S homeolog antibody, presenilin 2 (Alzheimer disease 4) antibody, trefoil factor 1 antibody, PSEN2 antibody, Psen2 antibody, psen2 antibody, psen2.S antibody, Tff1 antibody

Background: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

Molecular Weight: 50140

Gene ID: 5664

UniProt: P49810

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway