CD74 antibody (AA 1-232)

Catalog No. ABIN1944838

Product Details anti-CD74 Antibody

Target: CD74 (HLA-DR-gamma (CD74))

Binding Specificity: AA 1-232

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD74 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-232 amino acids from human.

Clone: 1267CT820-116-140-154

Isotype: IgG2b kappa

Application Details

Application Notes: WB: 1:1000. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CD74 antibody (ABIN1944838)

Kudo, Chao, Narni, Saunders: "Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens." in: Nucleic acids research, Vol. 13, Issue 24, pp. 8827-41, (1986) (PubMed).

OSullivan, Larhammar, Wilson, Peterson, Quaranta: "Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 12, pp. 4484-8, (1986) (PubMed).

Claesson, Larhammar, Rask, Peterson: "cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 24, pp. 7395-9, (1984) (PubMed).

Strubin, Mach, Long: "The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity." in: The EMBO journal, Vol. 3, Issue 4, pp. 869-72, (1984) (PubMed).

Target Details for CD74

Target: CD74 (HLA-DR-gamma (CD74))

Alternative Name: CD74 (CD74 Products)

Synonyms: DHLAG antibody, HLADG antibody, II antibody, Ia-GAMMA antibody, CLIP antibody, Ii antibody, INVG34 antibody, Iclp-1 antibody, iclp1 antibody, wu:fb11f09 antibody, wu:fb12a01 antibody, wu:fb13d06 antibody, wu:fk94e07 antibody, Iclp-2 antibody, cd74 antibody, iclp2 antibody, zgc:123161 antibody, CD74 molecule antibody, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antibody, CD74 molecule, major histocompatibility complex, class II invariant chain a antibody, CD74 molecule, major histocompatibility complex, class II invariant chain b antibody, CD74 antibody, Cd74 antibody, cd74a antibody, cd74b antibody

Background: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Molecular Weight: 33516

Gene ID: 972

UniProt: P04233

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints