CD74 antibody (HLA-DR-gamma) (AA 1-232)

Details for Product anti-CD74 Antibody No. ABIN1944838, Supplier: Log in to see
Antigen
  • CLIP
  • DHLAG
  • HLADG
  • Ia-GAMMA
  • Ii
  • II
  • INVG34
  • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
  • CD74 molecule, major histocompatibility complex, class II invariant chain
  • Cd74 molecule, major histocompatibility complex, class II invariant chain
  • Cd74
  • CD74
Alternatives
anti-Human CD74 antibody for Blocking Reagent
Epitope
AA 1-232
40
25
19
15
11
4
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
456
106
24
22
1
1
1
Host
Mouse
411
47
19
6
Clonality (Clone)
Monoclonal ()
Conjugate
This CD74 antibody is un-conjugated
27
26
20
18
16
15
15
14
14
11
11
10
10
10
10
10
9
9
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
1
1
1
1
1
1
Application
Western Blotting (WB)
336
264
184
152
131
115
102
98
65
13
11
4
3
3
3
2
2
1
1
1
1
1
Options
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Immunogen This antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 1-232 AA from human.
Clone 1267CT820-116-140-154
Isotype IgG2b
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name CD74 (CD74 Antibody Abstract)
Background Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
Synonyms: HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain, Ii, p33, CD74, CD74, DHLAG
Molecular Weight 33516 Da
Gene ID 972
UniProt P04233
Research Area Immunology, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells, Major Histocompatibility Complex (MHC)
Pathways Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling
Application Notes WB - 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Product cited in: Kudo, Chao, Narni, Saunders: "Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens." in: Nucleic acids research, Vol. 13, Issue 24, pp. 8827-41, 1986 (PubMed).

OSullivan, Larhammar, Wilson, Peterson, Quaranta: "Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 12, pp. 4484-8, 1986 (PubMed).

Claesson, Larhammar, Rask, Peterson: "cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 24, pp. 7395-9, 1984 (PubMed).

Strubin, Mach, Long: "The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity." in: The EMBO journal, Vol. 3, Issue 4, pp. 869-72, 1984 (PubMed).