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Product details for APP (Human) antibody
APP (Human) antibody
Overview
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| Antigen: | APP |
| Antibody Type: | Polyclonal |
| Application: | Western Blotting (WB) |
| Reactivity: | Human, Mouse, Rat |
| Host: | Rabbit |
| Quantity: | |
| Price: | 315,00 € (Plus shipping costs and VAT) |
| Order number: | ABIN195448 |
| Availability: | 10 days until shipment |
Additional Information: APP (Human) antibody
| Antigen | APP |
| Immunogen | Synthetic peptide of a part of Human APP (LEVPTDGNAGLLAEPQIAMFC) |
| Reactivity | Human, Mouse, Rat |
| Antibody Type | Polyclonal |
| Format | Lyophilized |
| Isotype | IgG »Matching secondary antibodies |
| Description | Amyloid precursor protein (APP) is precursor protein of Amyloid beta which is major constituent of senile plaque in Alzheimer’s disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative splicing of common precursor mRNA. Processing of APP occurs by two major pathways, non-amyloidogenic pathway and amyloidogenic pathway. The non-amyloidogenic pathway is mediated by alpha- and gamma-secretases and gives rise to a large fragment known as soluble APPbeta (sAPPbeta) and a small 3 kDa peptide known as p3. On the other hand, the amyloidogenic pathway is mediated by beta- and gamma-secretases and yields soluble APPbeta (sAPPbeta) and Amyloid beta. The physiologic function of APP itself is not clear, however, it is supposed that the function of APP in neuron system is different from that in other organ. |
| Host | Rabbit |
| Specificity | Reacts with Human, Mouse and Rat. Cross-reacts with sAPPalpha and sAPPbeta. |
Application Details: APP (Human) antibody
| Application | Western Blotting (WB) |
| Application Notes | This antibody can be used for western blotting in concentration of 1 - 5 ug/mL. 1.0 mL deionized water will be added to the product, then its concentration comes to 1-00 ug/mL. |
| Purification | Purified with antigen peptide |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 |
| Storage | Lyophilized product, 5 years at 2 - 8 °C. Solution, 2 years at –20 °C |
| Restrictions | For Research Use only |
External Information: APP (Human) antibody
| Google Scholar | Find more references for antigen APP on Google Scholar™ |
| EMBL Harvester | Search human, mouse or rat genome for antigen APP (Bioinformatic Harvester (EMBL)) |
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