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Amyloid beta (A4) Precursor Protein (APP) antibody

Antigen

Amyloid beta (A4) Precursor Protein (APP)
Synonyms APP, APP-like, APPL, Abeta, BcDNA:GH04413, EG:65F1.5, DmelCG7727, CG7727, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, CTFgamma, aaa, ad1, pn2, abpp, appi, cvap, abeta, MGC88882, ctfgamma
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus)
Application
Alternatives Western Blotting (WB)
Catalog no. ABIN195448
Quantity 100ug
Price 517.00 $   Plus shipping costs $35.00
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anti-Amyloid beta (A4) Precursor Protein (APP) antibody

Additional Information
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Alternative name APP
Immunogen Synthetic peptide of a part of Human APP (LEVPTDGNAGLLAEPQIAMFC)
Format Lyophilized
Isotype IgG  (Matching secondary antibodies)
Description Amyloid precursor protein (APP) is precursor protein of Amyloid beta which is major constituent of senile plaque in Alzheimer’s disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative splicing of common precursor mRNA. Processing of APP occurs by two major pathways, non-amyloidogenic pathway and amyloidogenic pathway. The non-amyloidogenic pathway is mediated by alpha- and gamma-secretases and gives rise to a large fragment known as soluble APPbeta (sAPPbeta) and a small 3 kDa peptide known as p3. On the other hand, the amyloidogenic pathway is mediated by beta- and gamma-secretases and yields soluble APPbeta (sAPPbeta) and Amyloid beta. The physiologic function of APP itself is not clear, however, it is supposed that the function of APP in neuron system is different from that in other organ.
Specificity Reacts with Human, Mouse and Rat. Cross-reacts with sAPPalpha and sAPPbeta.

Application Details
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Application Notes This antibody can be used for western blotting in concentration of 1 - 5 ug/mL. 1.0 mL deionized water will be added to the product, then its concentration comes to 1-00 ug/mL.
Purification Purified with antigen peptide
Buffer Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Storage Lyophilized product, 5 years at 2 - 8 °C. Solution, 2 years at –20 °C
Restrictions For Research Use only

Alternatives
Application Details Images Secondary Antibodies back to top

Alternatives for antigen "Amyloid beta (A4) Precursor Protein (APP)", type "Antibodies"
Hosts Rabbit (133), Mouse (62), Goat (22)
Reactivities Human (168), Mouse (Murine) (55), Rat (Rattus) (36), Dog (Canine) (5), Monkey (5), Chicken (4), Cow (Bovine) (4), Pig (Porcine) (3), Guinea Pig (2), Rabbit (2), Primate (1)
Applications Western Blotting (WB) (188), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (55), ELISA (47), Enzyme Immunoassay (EIA) (47), Immunofluorescence (IF) (38), Immunohistochemistry (IHC) (36), Flow Cytometry (FACS) (18), Immunoprecipitation (IP) (18), Immunohistochemistry (Frozen Sections) (IHC (fro)) (13), Dot Blot (Dot) (6), Immunocytochemistry (ICC) (3), Radioimmunoassay (RIA) (2)
Conjugates FITC (1)
Epitopes variant 1 (10), C-Term (9), N-Term (5), p668 (4), AA 653-662 (3), pThr668 (3), AA 292-312 (2), AA 44-63 (2), AA 671-685 (2), AA 747-761 (2), Ab-730 (2), pSer198 (2), pSer730 (2), pTyr756 (2), AA 1-14 (1), AA 350-450 (1), C-Term D672 (1), Carboxyl Terminal amino acids 737-751 (1), KPI Domain (1), Y756 (1), all isoforms (1), pS198 (1), pS730 (1), pThr743/668 (1)