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beta-Site APP-Cleaving Enzyme 1 (BACE) antibody
| Antigen | beta-Site APP-Cleaving Enzyme 1 (BACE) |
| Synonyms |
ASP2, BACE, HSPC104, FLJ90568, KIAA1149, C76936, Bace, bace1, MGC77409, BACE1, MGC137940, MGC145931, Bace1, ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, ARP1, AI850424, 1110059C24Rik, bace2, M ...
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| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Mouse (Murine), Rat (Rattus) |
| Application |
Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
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| Catalog no. | ABIN195449 |
| Quantity | 100ug |
| Price | 517.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 10 to 15 Business Days |
Additional Information
| Alternative name | BACE1 |
| Immunogen | Synthetic peptide of a part of human BACE1 (RLPRETDEEPEEPGRR) |
| Format | Lyophilized |
| Isotype | IgG (Matching secondary antibodies) |
| Description | The current understanding of the role of amyloid in Alzheimer's disease (AD) has been established by a remarkable congruence of multiple disciplines: neuropathology, biochemistry, molecular biology, and epidemiological genetics. It is known that amyloid beta is derived, by two sequential cleavages, from the receptor-like amyloid precursor protein (APP). The proteases involved are beta-secretase, identified as the novel aspartyl protease BACE, and gamma-secretase, a multimeric complex containing the presenilins (PS-1, PS-2). BACE1 and BACE2 have been isolated as homologue of BACE, and this antibody reacts to BACE1. (BACE: beta-site APP cleaving enzyme) |
| Specificity | Reacts with human, mouse and rat BACE1. |
| Synonyms | ASP2, BACE, HSPC104, FLJ90568, KIAA1149, C76936, Bace, bace1, MGC77409, BACE1, MGC137940, MGC145931, Bace1, ASP1, BAE2, DRAP, AEPLC, ALP56, ASP21, CDA13, CEAP1, ARP1, AI850424, 1110059C24Rik, bace2, MGC68881, MGC68482, BACE2 |
Application Details
| Application Notes | The antibody can be used in immunohistchemistry. The optimal dilution is 1 - 5 ug/mL, however, the dilution rate should be optimized by each laboratories. The antibody can be used for western blotting at 1 - 5 ug/mL. |
| Purification | Purified with antigen peptide |
| Buffer | Lyophilized product from 1% BSA in PBS containing 0.05% NaN3 |
| Storage | Lyophilized product, 5 years at 2 - 8 °C. Solution, 2 years at –20 °C |
| Restrictions | For Research Use only |
Images
| HEK293 cells stable transtected human BACE1 anti-beta-Site APP-Cleaving Enzyme 1 (BACE) antibody (Image 2) anti-beta-Site APP-Cleaving Enzyme 1 (BACE) antibody (Image 3) |
Alternatives
Alternatives for antigen "beta-Site APP-Cleaving Enzyme 1 (BACE)", type "Antibodies"
| Hosts | Rabbit (51), Mouse (6), Goat (2) |
| Reactivities | Human (51), Mouse (Murine) (21), Rat (Rattus) (6), Cow (Bovine) (1), Horse (Equine) (1), Pig (Porcine) (1), Rabbit (1) |
| Applications | Western Blotting (WB) (44), ELISA (19), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (17), Enzyme Immunoassay (EIA) (12), Flow Cytometry (FACS) (9), Immunofluorescence (IF) (6), Immunohistochemistry (IHC) (6), Immunoprecipitation (IP) (5), ELISA (Detection) (1), Immunocytochemistry (ICC) (1), Neutralization (Neut) (1) |
| Conjugates | APC (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), PE,Cy5.5 (1) |
| Epitopes | C-Term (3), N-Term (3), pSer498 (3), AA 26-45 (2), AA 46-65 (2), AA 485-501 (2), S498 (1), pS498 (1) |
