Voltage-Gated Potassium Channel, Subfamily H, Member 2 (KCNH2) antibody

Antigen: Voltage-Gated Potassium Channel, Subfamily H, Member 2 (KCNH2)

Synonyms: ERG1, HERG, LQT2, SQT1, HERG1, Kv11.1, KCNH2, cerg, derg, erg1, MGC143108

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Western Blotting (WB)

Catalog no.: ABIN195452

Additional Information

Alternative name: HERG1

Gene ID: 3757

Immunogen: GST fusion protein corresponding to aa 1106-1158 of HERG1 protein

Format: Antiserum

Description: Also known as: KCNH2 potassium voltage-gated channel, subfamily H (eag-related), member 2, ERG1, HERG, LQT2, SQT1, Kv11.1

Specificity: Recognizes human and Mouse C-term epitope of HERG1. Recognizes both isoforms HERG1A and HERG1B

Application Details

Application Notes: Immunohistochemistry on paraffin or frozen section (1:100 - 1:400), Immunocytochemistry (1:100 - 1:200), Western Blot (1:1000), Cytofluorimetry (1:1000)

Storage: Store the antibody at +4°C or -20°C. Avoid repeated freezing and thawing.

Research Area: Ion Channels

Restrictions: For Research Use only

Publications

Publications: Lastraioli, Guasti, Crociani et al.: "herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells." in: Cancer research, Vol. 64, Issue 2, pp. 606-11, 2004 (PubMed).

Cherubini, Hofmann, Pillozzi et al.: "Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling." in: Molecular biology of the cell, Vol. 16, Issue 6, pp. 2972-83, 2005 (PubMed).

Guasti, Cilia, Crociani et al.: "Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits." in: The Journal of comparative neurology, Vol. 491, Issue 2, pp. 157-74, 2005 (PubMed).

Masi, Becchetti, Restano-Cassulini et al.: "hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines." in: British journal of cancer, Vol. 93, Issue 7, pp. 781-92, 2005 (PubMed).