LGP2 (Human) antibody

Overview


	Antigen:	LGP2
	Antibody Type:	Polyclonal
	Application:	Western Blotting (WB)
	Reactivity:	Human
	Host:	Rabbit
	Quantity:	100ug
	Price:	315,00 € (Plus shipping costs and VAT)
	Order number:	ABIN195466
	Availability:	10 days until shipment

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Additional Information: LGP2 (Human) antibody

Antigen	LGP2
Immunogen	Synthetic peptide of part of c terminal of human LGP2 (IQAKKWSRVPFSV)
Reactivity	Human
Antibody Type	Polyclonal
Format	Affinity purified
Isotype	IgG »Matching secondary antibodies
Description	A full-length cDNA encoding mouse LGP2 was cloned by computational analysis, RT-PCR, and RACE of liver and mammary tissue total RNA. And human LGP2 was also cloned. Yoneyama et al. have identified a DExD/H box-containing RNA helicase, retinoic acid inducible gene I (RIG-I), as an essential component of the sensor of intracellular dsRNA (1). Furthermore, two other DexD/H-box-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database (2). MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIG-I/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses. Synonyms: LGP2 (NT): DHX58, likely ortholog of mouse D11lgp2
Host	Rabbit

Application Details: LGP2 (Human) antibody

Application	Western Blotting (WB)
Application Notes	Western blotting in concentration of 1 – 5?g/mL
Purification	Purified with antigen peptide
Buffer	Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Storage	Lyophilized product, 5 years at 2 – 8 ?. Solution, 2 years at –20 ?. 1.0 mL deionized water will be added to the product (the conc. comes up 100ug/ml)
Research Area	Virology, Immunology
Restrictions	For Research Use only

Images: LGP2 (Human) antibody

lane 1: HeLa cell lysate without IFN beta stimulation. lane 2: HeLa cell lysate with IFN beta stimulation. lane 3: L929 cell lysate without IFN beta stimulation. lane 4: L929 cell lysate with IFN beta stimulation When this antibody is used in Western Blotting, several bands appear although the antibody specifically detects the LGP2 protein. We recommend to perform positive and negative controls in parallel.

Image for LGP2 (Human) antibody (1)

Image for LGP2 (Human) antibody (2)

External Information: LGP2 (Human) antibody

Google Scholar	Find more references for antigen LGP2 on Google Scholar™
EMBL Harvester	Search human, mouse or rat genome for antigen LGP2 (Bioinformatic Harvester (EMBL))