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Details for Product No. ABIN195466

DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) antibody

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Antigen
Synonyms B430001I08Rik, D11Lgp2e, LPG2, Lgp2, RLR-3, RGD1310093, LGP2, D11LGP2, D11lgp2e, MGC82787, DHX58, lgp2
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN195466
Quantity 100 µg
Price
618.20 $   Plus shipping costs $45.00
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Availability Will be delivered in 8 to 11 Business Days
Immunogen Synthetic peptide of part of c terminal of human LGP2 (IQAKKWSRVPFSV)
Isotype IgG
Purification Purified with antigen peptide
Alternative Name LGP2
Background A full-length cDNA encoding mouse LGP2 was cloned by computational analysis, RT-PCR, and RACE of liver and mammary tissue total RNA. And human LGP2 was also cloned. Yoneyama et al. have identified a DExD/H box-containing RNA helicase, retinoic acid inducible gene I (RIG-I), as an essential component of the sensor of intracellular dsRNA (1). Furthermore, two other DexD/H-box-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database (2). MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIG-I/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses. Synonyms: LGP2 (NT): DHX58, likely ortholog of mouse D11lgp2
Research Area Virology, Immunology
Application Notes Western blotting in concentration of 1 – 5?g/mL
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Preservative Sodium azide
Storage 4 °C
Yoneyama, Kikuchi, Natsukawa et al.: "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses." in: Nature immunology, Vol. 5, Issue 7, pp. 730-7, 2004 (PubMed).

Yoneyama, Kikuchi, Matsumoto et al.: "Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 5, pp. 2851-8, 2005 (PubMed).

Alternatives for antigen "DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)", type "Antibodies"
Hosts (51), (6), (2)
Reactivities (53), (27), (26), (1), (1), (1), (1), (1), (1)
Applications (55), (37), (5), (4), (3), (1)
Epitopes (16), (15), (4), (3), (3), (2), (2), (1)
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