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DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) antibody

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(94), (25), (25), (2), (1), (1), (1)
(74), (16), (4)
(3), (3), (3), (3), (3), (3)
Western Blotting (WB)
(89), (56), (21), (6), (5), (5)
Pubmed 2 references available
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Quantity 100 μg
Shipping to United States ( )
Immunogen Synthetic peptide of part of c terminal of human LGP2 (IQAKKWSRVPFSV)
Isotype IgG
Purification Purified with antigen peptide
Alternative Name LGP2 (DHX58 Antibody Abstract)
Background A full-length cDNA encoding mouse LGP2 was cloned by computational analysis, RT-PCR, and RACE of liver and mammary tissue total RNA. And human LGP2 was also cloned. Yoneyama et al. have identified a DExD/H box-containing RNA helicase, retinoic acid inducible gene I (RIG-I), as an essential component of the sensor of intracellular dsRNA (1). Furthermore, two other DexD/H-box-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database (2). MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIG-I/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses. Synonyms: LGP2 (NT): DHX58, likely ortholog of mouse D11lgp2
Research Area Virology, Immunology
Application Notes Western blotting in concentration of 1 – 5?g/mL
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Yoneyama, Kikuchi, Matsumoto et al.: "Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 5, pp. 2851-8, 2005 (PubMed).

Yoneyama, Kikuchi, Natsukawa et al.: "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses." in: Nature immunology, Vol. 5, Issue 7, pp. 730-7, 2004 (PubMed).

Catalog No. ABIN195466

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