Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN195466

DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) antibody

Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms B430001I08Rik, D11Lgp2e, LPG2, Lgp2, RLR-3, RGD1310093, LGP2, D11LGP2, D11lgp2e, MGC82787, DHX58, lgp2
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN195466
Quantity 100 µg
618.20 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 8 to 11 Business Days
Immunogen Synthetic peptide of part of c terminal of human LGP2 (IQAKKWSRVPFSV)
Isotype IgG
Purification Purified with antigen peptide
Alternative Name LGP2
Background A full-length cDNA encoding mouse LGP2 was cloned by computational analysis, RT-PCR, and RACE of liver and mammary tissue total RNA. And human LGP2 was also cloned. Yoneyama et al. have identified a DExD/H box-containing RNA helicase, retinoic acid inducible gene I (RIG-I), as an essential component of the sensor of intracellular dsRNA (1). Furthermore, two other DexD/H-box-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database (2). MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIG-I/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses. Synonyms: LGP2 (NT): DHX58, likely ortholog of mouse D11lgp2
Research Area Virology, Immunology
Application Notes Western blotting in concentration of 1 – 5?g/mL
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Preservative Sodium azide
Storage 4 °C
Yoneyama, Kikuchi, Natsukawa et al.: "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses." in: Nature immunology, Vol. 5, Issue 7, pp. 730-7, 2004 (PubMed).

Yoneyama, Kikuchi, Matsumoto et al.: "Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 5, pp. 2851-8, 2005 (PubMed).

Alternatives for antigen "DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58)", type "Antibodies"
Hosts (51), (6), (2)
Reactivities (53), (27), (26), (1), (1), (1), (1), (1), (1)
Applications (55), (37), (5), (4), (3), (1)
Epitopes (16), (15), (4), (3), (3), (2), (2), (1)