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Interferon Induced with Helicase C Domain 1 (IFIH1) antibody

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Antigen
Reactivity
Human
(111), (43), (4), (2), (1)
Host
Rabbit
(75), (33), (22)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(89), (61), (44), (20), (11), (8), (5), (3), (3), (1), (1), (1)
Pubmed 2 references available
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Quantity 100 μg
Shipping to United States ( )
Availability
Immunogen Synthetic peptide of part of N terminal of human MDA5 (TIEDRNRIAAAENNGN)
Isotype IgG
Purification Purified with antigen peptide
Alternative Name MDA5 (IFIH1 Antibody Abstract)
Background A full-length cDNA encoding MDA5 was isolated by screening a melanoma differentiation-subtracted library and a placenta cDNA library, also known as Ifih1(Interferon induced with helicase C domain protein 1). Yoneyama et al. have identified a DExD/H box-containing RNA helicase, retinoic acid inducible gene I (RIG-I), as an essential component of the sensor of intracellular dsRNA (1). Furthermore, two other DexD/H-box-containing RNA helicases, MDA5 and LGP2, were found in the mammalian database (2). MDA5 acts as a positive regulator in the virus-induced activation of type I IFN genes. On the other hand, LGP2 functions as a dominant-negative regulator of RIG-I/MDA5-mediated signaling. These molecules have critical roles for antiviral innate immune responses.
Research Area Virology, Immunology
Application Notes Western blotting in concentration of 1 – 5?g/mL
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Background publications Yoneyama, Kikuchi, Matsumoto et al.: "Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 5, pp. 2851-8, 2005 (PubMed).

Yoneyama, Kikuchi, Natsukawa et al.: "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses." in: Nature immunology, Vol. 5, Issue 7, pp. 730-7, 2004 (PubMed).

Catalog No. ABIN195468

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