Tuberous Sclerosis 1 (TSC1) antibody

Details for Product No. ABIN195469
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Synonyms tsc1, wu:fc38b04, LAM, TSC, hamartin, mKIAA0243
(357), (287), (124), (5), (1), (1), (1), (1), (1), (1)
(593), (31), (19), (1)
(68), (68), (68), (65), (65), (65), (3), (3), (3), (3), (3), (3), (3), (3)
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(449), (361), (137), (96), (56), (30), (25), (16), (12), (8), (5), (3), (2), (2), (1)
Pubmed 5 references available
Quantity 100 μg
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Catalog No. ABIN195469
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Immunogen The synthetic peptide of a part of Human TSC1/Hamartin (GQLHIMDYNETHHEHS)
Isotype IgG
Specificity Crossreactivities with mouse
Purification Purified with antigen peptide
Alternative Name TSC1/Hamartin
Background TSC1 is a tumor-suppressor gene encoding a protein TSC1/Hamartin of about 130 kDa (ref. 1). Loss of its function causes TSC (tuberous sclerosis complex) or angiomyolipoma in human and in an animal model, TSC1 knockout mouse develops a renal tumor (ref. 2). TSC1/Hamartin, a product of TSC1, forms a complex with TSC2/Tuberin (ref. 3), a product of another tumor-suppressor gene TSC2 in cytoplasm (ref. 4). The complex suppresses mTOR activity and regulates cellular growth and division in a insulin signaling pathway (ref. 5). Under the condition of proliferation stimulus, forming of the complex is inhibited, and as a result, suppression to mTOR comes off and it leads to cellular growth and division.
Research Area Cancer, Diabetes
Application Notes This antibody can be stained in formalin fixed paraffin embedded tissues by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 1 - 5 ?g /mL, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 1 - 5 ?g /mL.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-Tuberous Sclerosis 1 (TSC1) antibody anti-Tuberous Sclerosis 1 (TSC1) antibody
anti-Tuberous Sclerosis 1 (TSC1) antibody (2) Human Pancreas
General Kobayashi, Minowa, Sugitani et al.: "A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 15, pp. 8762-7, 2001 (PubMed).

Gao, Pan: "TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth." in: Genes & development, Vol. 15, Issue 11, pp. 1383-92, 2001 (PubMed).

Plank, Yeung, Henske: "Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles." in: Cancer research, Vol. 58, Issue 21, pp. 4766-70, 1998 (PubMed).

van Slegtenhorst, de Hoogt, Hermans et al.: "Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. ..." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 805-8, 1997 (PubMed).

"Identification and characterization of the tuberous sclerosis gene on chromosome 16." in: Cell, Vol. 75, Issue 7, pp. 1305-15, 1994 (PubMed).

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