Girdin (S1416 Phosphorylated) (Human) antibody

Overview


	Antigen:	Girdin (S1416 Phosphorylated)
	Antibody Type:	Polyclonal
	Application:	Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
	Reactivity:	Human
	Host:	Rabbit
	Quantity:	100ug
	Price:	355,00 € (Plus shipping costs and VAT)
	Order number:	ABIN195492
	Availability:	10 days until shipment

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Additional Information: Girdin (S1416 Phosphorylated) (Human) antibody

Antigen	Girdin (S1416 Phosphorylated)
Immunogen	Synthetic peptide of the phosphorylated part of of Human Girdin (DINRERQK(pS)LTLT)
Reactivity	Human
Antibody Type	Polyclonal
Format	Affinity purified
Isotype	IgG »Matching secondary antibodies
Description	Girdin was discovered by a study group led by Takahashi as a new protein playing an important role in the infiltration and metastasis of cancer cells. It has been shown that Girdin, phosphorylated by the enzyme Akt/PKB within cancer cells, enhances the infiltration potential of cancer cells. It has, therefore, been suggested that if the activity of girdin is suppressed, it may be possible to develop a drug which can suppress the progression of cancer.
Host	Rabbit
Specificity	Specific for phosphorylated Girdin

Application Details: Girdin (S1416 Phosphorylated) (Human) antibody

Application	Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Application Notes	This antibody can be stained in formalin fixed paraffin embedded tissues by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 1 - 2 ug/mL, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 2 - 4 ug /mL.
Format	Affinity purified
Purification	Purified with antigen peptide
Buffer	Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Storage	Lyophilized product, 5 years at 2 – 8°C. Solution, 2 years at –20 °C. 1.0 mL deionized water will be added to the product (the conc. comes up 100ug/ml)
Research Area	Cancer
Restrictions	For Research Use only

Publications: Girdin (S1416 Phosphorylated) (Human) antibody

Publications

Enomoto, Murakami, Asai et al.:
"Akt/PKB regulates actin organization and cell motility via Girdin/APE."
In: Developmental cell , Vol. 9, Issue 3, pp. 389-402, 2005/01 (PubMed)

Enomoto, Ping, Takahashi:
"Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways."
In: Annals of the New York Academy of Sciences , Vol. 1086, pp. 169-84, 2006/01 (PubMed)

Kitamura, Asai, Enomoto et al.:
"Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin."
In: Nature cell biology , Vol. 10, Issue 3, pp. 329-37, 2008/01 (PubMed)

Jiang, Enomoto, Jijiwa et al.:
"An actin-binding protein Girdin regulates the motility of breast cancer cells."
In: Cancer research , Vol. 68, Issue 5, pp. 1310-8, 2008/01 (PubMed)

Images: Girdin (S1416 Phosphorylated) (Human) antibody

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External Information: Girdin (S1416 Phosphorylated) (Human) antibody

Google Scholar	Find more references for antigen Girdin (S1416 Phosphorylated) on Google Scholar™
EMBL Harvester	Search human, mouse or rat genome for antigen Girdin (S1416 Phosphorylated) (Bioinformatic Harvester (EMBL))