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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Coiled-Coil Domain Containing 88A (CCDC88A) (S1416 prylated) antibody
|Synonyms||APE, GIV, GRDN, HkRP1, GIRDIN, KIAA1212, DKFZp686D0630, Ape, Giv, Hkrp1, Girdin, AI848406, RP23-92B18.2, A430106J12Rik, C130096N06Rik, C330012F17Rik, D130005J21Rik, DKFZp459N1815, ccdc88a, MGC175202|
Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
|4 references available|
|Price||618.20 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 8 to 11 Business Days|
|Alternative name||Girdin (S1416 Phosphorylated)|
|Immunogen||Synthetic peptide of the phosphorylated part of of Human Girdin (DINRERQK(pS)LTLT)|
|Description||Girdin was discovered by a study group led by Takahashi as a new protein playing an important role in the infiltration and metastasis of cancer cells. It has been shown that Girdin, phosphorylated by the enzyme Akt/PKB within cancer cells, enhances the infiltration potential of cancer cells. It has, therefore, been suggested that if the activity of girdin is suppressed, it may be possible to develop a drug which can suppress the progression of cancer.|
|Specificity||Specific for phosphorylated Girdin|
|Application Notes||This antibody can be stained in formalin fixed paraffin embedded tissues by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 1 - 2 ug/mL, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 2 - 4 ug /mL.|
|Purification||Purified with antigen peptide|
|Buffer||Lyophilized product from 1% BSA in PBS containing 0.05% NaN3|
|Storage||Lyophilized product, 5 years at 2 – 8°C. Solution, 2 years at –20 °C. 1.0 mL deionized water will be added to the product (the conc. comes up 100ug/ml)|
|Restrictions||For Research Use only|
|anti-Coiled-Coil Domain Containing 88A (CCDC88A) (S1416 prylated) antibody anti-Coiled-Coil Domain Containing 88A (CCDC88A) (S1416 prylated) antibody (Image 2) anti-Coiled-Coil Domain Containing 88A (CCDC88A) (S1416 prylated) antibody (Image 3)|
Enomoto, Murakami, Asai et al.: "Akt/PKB regulates actin organization and cell motility via Girdin/APE." in: Developmental cell, Vol. 9, Issue 3, pp. 389-402, 2005 (PubMed).
Enomoto, Ping, Takahashi: "Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways." in: Annals of the New York Academy of Sciences, Vol. 1086, pp. 169-84, 2006 (PubMed).
Kitamura, Asai, Enomoto et al.: "Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin." in: Nature cell biology, Vol. 10, Issue 3, pp. 329-37, 2008 (PubMed).
Jiang, Enomoto, Jijiwa et al.: "An actin-binding protein Girdin regulates the motility of breast cancer cells." in: Cancer research, Vol. 68, Issue 5, pp. 1310-8, 2008 (PubMed).
|Reactivities||Human (33), Mouse (Murine) (23), Rat (Rattus) (21), Dog (Canine) (18), Horse (Equine) (18)|
|Applications||Immunofluorescence (IF) (15), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (12), ELISA (10), Western Blotting (WB) (9), Immunohistochemistry (IHC) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (6), pTyr1756 (3), Internal Region (1), pSer1417 (1)|