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Coiled-Coil Domain Containing 88A (CCDC88A) (pSer1416) antibody

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(21), (11), (3), (2), (2), (1), (1), (1), (1), (1)
(66), (48), (36)
(3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(26), (24), (19), (19), (17), (2), (2), (2)
Pubmed 4 references available
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Quantity 100 μg
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Immunogen Synthetic peptide of the phosphorylated part of of Human Girdin (DINRERQK(pS)LTLT)
Isotype IgG
Specificity Specific for phosphorylated Girdin
Purification Purified with antigen peptide
Alternative Name Girdin (S1416 Phosphorylated) (CCDC88A Antibody Abstract)
Background Girdin was discovered by a study group led by Takahashi as a new protein playing an important role in the infiltration and metastasis of cancer cells. It has been shown that Girdin, phosphorylated by the enzyme Akt/PKB within cancer cells, enhances the infiltration potential of cancer cells. It has, therefore, been suggested that if the activity of girdin is suppressed, it may be possible to develop a drug which can suppress the progression of cancer.
Research Area Cancer
Application Notes This antibody can be stained in formalin fixed paraffin embedded tissues by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 1 - 2 ug/mL, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 2 - 4 ug /mL.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
Image no. 1 for anti-Coiled-Coil Domain Containing 88A (CCDC88A) (pSer1416) antibody (ABIN195492) anti-Coiled-Coil Domain Containing 88A (CCDC88A) (pSer1416) antibody
Image no. 2 for anti-Coiled-Coil Domain Containing 88A (CCDC88A) (pSer1416) antibody (ABIN195492) anti-Coiled-Coil Domain Containing 88A (CCDC88A) (pSer1416) antibody (Image 2)
Image no. 3 for anti-Coiled-Coil Domain Containing 88A (CCDC88A) (pSer1416) antibody (ABIN195492) anti-Coiled-Coil Domain Containing 88A (CCDC88A) (pSer1416) antibody (Image 3)
Background publications Jiang, Enomoto, Jijiwa et al.: "An actin-binding protein Girdin regulates the motility of breast cancer cells." in: Cancer research, Vol. 68, Issue 5, pp. 1310-8, 2008 (PubMed).

Kitamura, Asai, Enomoto et al.: "Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin." in: Nature cell biology, Vol. 10, Issue 3, pp. 329-37, 2008 (PubMed).

Enomoto, Ping, Takahashi: "Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways." in: Annals of the New York Academy of Sciences, Vol. 1086, pp. 169-84, 2006 (PubMed).

Enomoto, Murakami, Asai et al.: "Akt/PKB regulates actin organization and cell motility via Girdin/APE." in: Developmental cell, Vol. 9, Issue 3, pp. 389-402, 2005 (PubMed).

Catalog No. ABIN195492

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