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Details for Product No. ABIN195492

Coiled-Coil Domain Containing 88A (CCDC88A) (pSer1416) antibody

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Antigen
Synonyms APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212, A430106J12Rik, AI848406, Ape, C130096N06Rik, C330012F17Rik, D130005J21Rik, Girdin, Giv, Grdn, Hkrp1, RGD1306694, DKFZp459N1815, ccdc88a, MGC175202
Epitope
»Alternatives pSer1416
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 4 references available
Catalog no. ABIN195492
Quantity 100 µg
Price
618.20 $   Plus shipping costs $45.00
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Availability Will be delivered in 8 to 11 Business Days
Immunogen Synthetic peptide of the phosphorylated part of of Human Girdin (DINRERQK(pS)LTLT)
Isotype IgG
Specificity Specific for phosphorylated Girdin
Purification Purified with antigen peptide
Alternative Name Girdin (S1416 Phosphorylated)
Background Girdin was discovered by a study group led by Takahashi as a new protein playing an important role in the infiltration and metastasis of cancer cells. It has been shown that Girdin, phosphorylated by the enzyme Akt/PKB within cancer cells, enhances the infiltration potential of cancer cells. It has, therefore, been suggested that if the activity of girdin is suppressed, it may be possible to develop a drug which can suppress the progression of cancer.
Research Area Cancer
Application Notes This antibody can be stained in formalin fixed paraffin embedded tissues by several Immunohistochemical techniques such as Avidin Biotin Complex (ABC) Method. The optimal dilution is 1 - 2 ug/mL, however, the dilution rate should be optimized by each laboratories. This antibody can be used for western blotting in concentration of 2 - 4 ug /mL.
Restrictions For Research Use only
Format Lyophilized
Buffer Lyophilized product from 1% BSA in PBS containing 0.05% NaN3
Preservative Sodium azide
Storage 4 °C
Enomoto, Murakami, Asai et al.: "Akt/PKB regulates actin organization and cell motility via Girdin/APE." in: Developmental cell, Vol. 9, Issue 3, pp. 389-402, 2005 (PubMed).

Enomoto, Ping, Takahashi: "Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways." in: Annals of the New York Academy of Sciences, Vol. 1086, pp. 169-84, 2006 (PubMed).

Kitamura, Asai, Enomoto et al.: "Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin." in: Nature cell biology, Vol. 10, Issue 3, pp. 329-37, 2008 (PubMed).

Jiang, Enomoto, Jijiwa et al.: "An actin-binding protein Girdin regulates the motility of breast cancer cells." in: Cancer research, Vol. 68, Issue 5, pp. 1310-8, 2008 (PubMed).

Alternatives for antigen "Coiled-Coil Domain Containing 88A (CCDC88A)", type "Antibodies"
Hosts (54)
Reactivities (54), (29), (20), (12)
Applications (25), (20), (20), (16), (13)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (12), (11), (5), (3), (1)
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