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Nibrin antibody (pSer343)

NBN Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN196714
  • Target See all Nibrin (NBN) Antibodies
    Nibrin (NBN)
    Binding Specificity
    • 37
    • 15
    • 12
    • 8
    • 7
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer343
    Reactivity
    • 102
    • 62
    • 36
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 121
    • 15
    Rabbit
    Clonality
    • 109
    • 27
    Polyclonal
    Conjugate
    • 70
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This Nibrin antibody is un-conjugated
    Application
    • 107
    • 45
    • 30
    • 27
    • 26
    • 26
    • 26
    • 18
    • 12
    • 11
    • 6
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Specificity
    The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site. This antibody detects endogenous levels of p95/NBS1 only when phosphorylated at Serine 343.
    Purification
    Affinity Chromatography using epitope-specific peptide
    Immunogen
    The antiserum was produced against synthesized phosphopeptide derived from Human p95/NBS1 around the phosphorylation site of Serine 343 (S-L-Sp-Q-G).
    Top Product
    Discover our top product NBN Primary Antibody
  • Application Notes
    Western blot (1: 500-1: 1000).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at -20 °C.
  • Target
    Nibrin (NBN)
    Alternative Name
    Nibrin (NBN Products)
    Synonyms
    NBN antibody, AT-V1 antibody, AT-V2 antibody, ATV antibody, NBS antibody, NBS1 antibody, P95 antibody, Nbs1 antibody, im:6911679 antibody, zgc:194152 antibody, nibrin antibody, NBN antibody, nbn antibody, Nbn antibody
    Background
    The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex (MRN complex). This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions. In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells. NBS1 is expressed ubiquitously and presents high levels in testis.Synonyms: Cell cycle regulatory protein p95, NBN, NBS, NBS1, Nijmegen breakage syndrome protein 1, P95
    Gene ID
    4683
    NCBI Accession
    NP_002476
    UniProt
    O60934
    Pathways
    DNA Damage Repair, Production of Molecular Mediator of Immune Response
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