Keratin 18 (KRT18) (pSer33) antibody

Details for Product No. ABIN197076
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Antigen
Synonyms krt18, MGC64569, MGC75922, KRT18, CYK18, K18, CK18, Krt1-18, DreK18, cb83, dapk1, sb:cb83, wu:fa13f02, wu:fb36b04, krtt1c6, zgc:66015
Epitope
pSer33
(41), (18), (15), (12), (12), (8), (8), (6), (6), (6), (5), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(432), (110), (103), (44), (38), (36), (29), (12), (12), (9), (7), (6), (5), (5), (4), (4), (4), (3), (2), (1), (1)
Host
Rabbit
(250), (214), (9), (4), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(31), (28), (8), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(335), (198), (131), (129), (103), (103), (90), (72), (50), (43), (10), (4), (3), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN197076
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Immunogen The antiserum was produced against synthesized phosphopeptide derived from human Keratin 18 around the phosphorylation site of serine 33 (A-A-SP-V-Y).
Specificity Keratin 18 antibody detects endogenous levels of Keratin 18 only when phosphorylated at serine 33.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Alternative Name Cytokeratin 18
Background Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only Cytokeratins 8 and 18.
Alternate names: CK18, CYK18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, K18, KRT18, Keratin 18, Keratin type I cytoskeletal 18, Keratin-18
Gene ID 3875
NCBI Accession NP_000215
UniProt P05783
Research Area Signaling, Cytoskeleton, Extracellular Matrix
Application Notes Immunohistochemistry: 1: 50~1: 100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS(without Mg2+ and Ca2+), pH 7.4 containing 150mM NaCl, 0.02% sodium azide and 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Supplier Images
anti-Keratin 18 (KRT18) (pSer33) antibody anti-Keratin 18 (KRT18) (pSer33) antibody
Background publications Collin, Moll, Kubicka et al.: "Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation." in: Experimental cell research, Vol. 202, Issue 1, pp. 132-41, 1992 (PubMed).

Chang, Goldman: "Intermediate filaments mediate cytoskeletal crosstalk." in: Nature reviews. Molecular cell biology, Vol. 5, Issue 8, pp. 601-13, 2004 (PubMed).

Ramaekers, Bosman: "The cytoskeleton and disease." in: The Journal of pathology, Vol. 204, Issue 4, pp. 351-4, 2004 (PubMed).

Validation Images
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