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Glycogen Synthase Kinase 3 alpha (GSK3a) (Ser21) antibody

Details for Product No. ABIN197105
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Antigen
Synonyms GSK3A, CG5182, Dmel\\CG5182, GSK3a, 2700086H06Rik, xgsk3, GSK-3[a], GSK-3[b], GSK3, gsk3a
Epitope
Ser21
(62), (26), (18), (7), (6), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(209), (117), (109), (38), (36), (27), (13), (6), (4), (2)
Host
Rabbit
(160), (65), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(14), (7), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(183), (81), (74), (40), (36), (30), (25), (9), (6), (1)
Pubmed 5 references available
Quantity 50 µg
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Catalog No. ABIN197105
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Immunogen Synthetic non-phosphopeptide derived from human GSK3alpha around the phosphorylation site of serine 21 (T-S-SP-F-A).
Specificity GSK3alpha Antibody detects endogenous levels of total GSK3alpha protein.
Purification Affinity chromatography
Alternative Name GSK3 alpha
Background Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily, GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.
Alternate names: Factor A, GSK-3 alpha, GSK3A, Glycogen synthase kinase-3 alpha
Gene ID 2931
NCBI Accession NP_063937.2
UniProt P49840
Research Area Cardiovascular, Hypertrophy, Atherosclerosis, Wnt, Kinases/Phosphatases
Application Notes Western Blot: 1: 500~1: 1000. Immunohistochemistry: 1: 50~1: 100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS(without Mg2+ and Ca2+), pH 7.4 containing 150mM NaCl, 0.02% sodium azide and 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Supplier Images
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (Ser21) antibody anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (Ser21) antibody
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (Ser21) antibody (2) anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (Ser21) antibody (Image 2)
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (Ser21) antibody (3) anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (Ser21) antibody (Image 3)
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (Ser21) antibody (4) anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (Ser21) antibody (Image 4)
Background publications Cross, Alessi, Cohen et al.: "Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B." in: Nature, Vol. 378, Issue 6559, pp. 785-9, 1996 (PubMed).

Srivastava, Pandey: "Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin." in: Molecular and cellular biochemistry, Vol. 182, Issue 1-2, pp. 135-41, 1999 (PubMed).

Koivisto, Alavian, Hakkinen et al.: "Glycogen synthase kinase-3 regulates formation of long lamellipodia in human keratinocytes." in: Journal of cell science, Vol. 116, Issue Pt 18, pp. 3749-60, 2003 (PubMed).

Barry, Graham, Fry et al.: "Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function?" in: FEBS letters, Vol. 553, Issue 1-2, pp. 173-8, 2003 (PubMed).

Welsh, Wilson, Proud: "GSK3: a SHAGGY frog story." in: Trends in cell biology, Vol. 6, Issue 7, pp. 274-9, 2004 (PubMed).

Validation Images
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