You are viewing an incomplete version of our website. Please click to reload the website as full version.

STAT5A antibody (Signal Transducer and Activator of Transcription 5A) (Tyr694)

Details for Product anti-STAT5A Antibody No. ABIN197180, Supplier: Log in to see
Antigen
  • STAT5A
  • STAT5
  • MGF
  • AA959963
  • Stat5
  • STAT5A/MGF
  • STATA5
Alternatives
anti-Human STAT5A antibody for Immunohistochemistry (Frozen Sections)
Epitope
Tyr694
88
52
42
18
14
13
9
6
6
6
5
5
5
4
4
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
408
197
160
28
21
17
13
11
6
1
Host
Rabbit
324
97
10
Clonality
Polyclonal
Conjugate
This STAT5A antibody is un-conjugated
12
11
10
8
6
5
5
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
323
195
132
55
54
51
33
25
18
17
12
9
6
4
4
2
2
1
1
1
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human STAT5A around the phosphorylation site of Tyrosine 694 (D-G-YP-V-K).
Specificity This antibody detects endogenous levels of total STAT5A around Tyrosine 694.
Purification Affinity Chromatography using epitope-specific immunogen
Alternative Name STAT5 / STAT5A (STAT5A Antibody Abstract)
Background STAT5a protein is a transcription factor activated by hormone and cytokines. Two highly related, but distinct Stat 5 genes (Stat 5a and Stat 5b) were identified in mouse. The amino acid sequences of Stat 5a and Stat 5b show 96 % sequence similarity, and both proteins are co expressed in most tissues of both virgin and lactating mice. However, differential accumulation of Stat 5a and Stat 5b mRNA has been reported for both muscle and mammary tissue. Stat 5a is critically involved in a variety of physiological functions, including reproduction, lactation, immune function and somatic growth.Synonyms: MGF, Mammary gland factor, STAT-5, STAT-5A, Signal transducer and activator of transcription 5A
Gene ID 6776
NCBI Accession NP_003143
UniProt P42229
Pathways JAK-STAT Signaling, RTK Signaling
Application Notes Western Blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
 image for anti-STAT5A antibody (Signal Transducer and Activator of Transcription 5A) (Tyr694) (ABIN197180) anti-Signal Transducer and Activator of Transcription 5A (STAT5A) (Tyr694) antibody
 image for anti-STAT5A antibody (Signal Transducer and Activator of Transcription 5A) (Tyr694) (ABIN197180) anti-Signal Transducer and Activator of Transcription 5A (STAT5A) (Tyr694) antibody (Image 2)
Background publications Dentelli, Del Sorbo, Rosso et al.: "Human IL-3 stimulates endothelial cell motility and promotes in vivo new vessel formation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 4, pp. 2151-9, 1999 (PubMed).

Gouilleux, Wakao, Mundt et al.: "Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription." in: The EMBO journal, Vol. 13, Issue 18, pp. 4361-9, 1994 (PubMed).