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Retinoblastoma 1 antibody (RB1) (Ser780)

Details for Product anti-RB1 Antibody No. ABIN197285, Supplier: Login to see New
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Antigen
Alternatives
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Epitope
Ser780
(54), (52), (49), (41), (35), (28), (26), (21), (17), (17), (16), (13), (9), (8), (8), (8), (7), (7), (7), (6), (6), (5), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(526), (254), (230), (11), (8), (7), (5), (5), (4), (4), (3), (3), (2), (2)
Host
Rabbit
(467), (68), (3)
Clonality
Polyclonal
Conjugate
This Retinoblastoma 1 antibody is un-conjugated
(22), (20), (20), (15), (13), (13), (10), (9), (9), (7), (7), (7), (7), (7), (7)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(323), (215), (183), (83), (74), (72), (44), (35), (15), (13), (10), (8), (6), (5), (2), (2), (2), (1), (1)
Pubmed 3 references available
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Quantity 50 μL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthesized non-phosphopeptide derived from human Rb around the phosphorylation site of serine 780.
Sequence T-L-SP-P-I
Specificity This antibody detects endogenous levels of total Rb protein.
Purification Affinity-chromatography using epitope-specific immunogen
Alternative Name Retinoblastoma-Associated Protein / RB1 (RB1 Antibody Abstract)
Background Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110
Gene ID 5925
NCBI Accession NP_000312
UniProt P06400
Pathways Cell Division Cycle
Application Notes Western blot (1: 500 - 1: 1000). Immunohistochemistry (1: 50 - 1: 100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Supplier Images
 image for anti-Retinoblastoma 1 antibody (RB1) (Ser780) (ABIN197285) anti-Retinoblastoma 1 (RB1) (Ser780) antibody
 image for anti-Retinoblastoma 1 antibody (RB1) (Ser780) (ABIN197285) anti-Retinoblastoma 1 (RB1) (Ser780) antibody (Image 2)
Background publications Roesch, Becker, Meyer et al.: "Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 18, Issue 4, pp. 565-72, 2005 (PubMed).

Huang, Zegarra-Moro, Benson et al.: "Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells." in: Oncogene, Vol. 23, Issue 12, pp. 2161-76, 2004 (PubMed).

Kitagawa, Higashi, Jung et al.: "The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2." in: The EMBO journal, Vol. 15, Issue 24, pp. 7060-9, 1997 (PubMed).

Catalog No. ABIN197285
$253.00
Plus shipping costs $45.00

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