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Retinoblastoma 1 (RB1) (Ser780) antibody

Details for Product No. ABIN197285
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Antigen
Synonyms RB1, OSRC, RB, p105-Rb, pRb, pp110, Rb, Rb-1, zgc:154147, P105-RB, PP110, RB11
Epitope
Ser780
(32), (31), (28), (21), (19), (19), (17), (17), (17), (14), (12), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(339), (226), (214), (109), (85), (65), (48), (7), (1), (1), (1)
Host
Rabbit
(298), (54), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (10), (10), (10), (10), (10), (10), (10), (10), (10), (10)
Application
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(212), (100), (94), (87), (80), (34), (31), (18), (11), (7), (2), (1)
Pubmed 3 references available
Quantity 50 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN197285
253.00 $
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Immunogen Synthesized non-phosphopeptide derived from human Rb around the phosphorylation site of serine 780.
Sequence T-L-SP-P-I
Specificity This antibody detects endogenous levels of total Rb protein.
Purification Affinity-chromatography using epitope-specific immunogen
Alternative Name Retinoblastoma-associated protein / RB1
Background Alternate names: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110
Gene ID 5925
NCBI Accession NP_000312.2
UniProt P06400
Application Notes Western blot (1: 500 - 1: 1000). Immunohistochemistry (1: 50 - 1: 100). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Expiry Date 12 months
Supplier Images
anti-Retinoblastoma 1 (RB1) (Ser780) antibody anti-Retinoblastoma 1 (RB1) (Ser780) antibody
anti-Retinoblastoma 1 (RB1) (Ser780) antibody (2) anti-Retinoblastoma 1 (RB1) (Ser780) antibody (Image 2)
Background publications Kitagawa, Higashi, Jung et al.: "The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2." in: The EMBO journal, Vol. 15, Issue 24, pp. 7060-9, 1997 (PubMed).

Huang, Zegarra-Moro, Benson et al.: "Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells." in: Oncogene, Vol. 23, Issue 12, pp. 2161-76, 2004 (PubMed).

Roesch, Becker, Meyer et al.: "Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 18, Issue 4, pp. 565-72, 2005 (PubMed).

Validation Images
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