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Caveolin-1 antibody (Caveolin 1, Caveolae Protein, 22kDa) (Tyr14)

Details for Product anti-CAV1 Antibody No. ABIN197289, Supplier: Log in to see
Antigen
Epitope
Tyr14
37
28
20
11
9
8
7
5
5
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
230
110
104
24
17
9
9
8
8
6
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
Host
Rabbit
184
35
32
3
Clonality
Polyclonal
Conjugate
This Caveolin-1 antibody is un-conjugated
6
4
3
2
1
1
1
1
1
1
Application
Western Blotting (WB)
186
65
53
50
48
29
19
9
5
5
4
2
2
1
Supplier
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Immunogen Synthesized non-phosphopeptide derived from human Caveolin-1 around the phosphorylation site of tyrosine 14
Sequence H-L-YP-T-V
Specificity This antibody detects endogenous levels of total Caveolin-1 protein.
Purification Affinity-chromatography using epitope-specific immunogen
Alternative Name Caveolin-1 (CAV1 Antibody Abstract)
Background Synonyms: CAV1
Gene ID 857
NCBI Accession NP_001744
UniProt Q03135
Research Area Signaling
Application Notes Western blot: (1: 500 - 1: 1000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Supplier Images
 image for anti-Caveolin-1 antibody (Caveolin 1, Caveolae Protein, 22kDa) (Tyr14) (ABIN197289) anti-Caveolin 1, Caveolae Protein, 22kDa (CAV1) (Tyr14) antibody
Background publications Zhang, Wolf-Yadlin, Ross et al.: "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules." in: Molecular & cellular proteomics : MCP, Vol. 4, Issue 9, pp. 1240-50, 2005 (PubMed).

Labrecque, Nyalendo, Langlois et al.: "Src-mediated tyrosine phosphorylation of caveolin-1 induces its association with membrane type 1 matrix metalloproteinase." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 52132-40, 2004 (PubMed).

Fielding, Chau, Liu et al.: "Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: relationship to sterol binding and the role of serine-80." in: Biochemistry, Vol. 43, Issue 9, pp. 2578-86, 2004 (PubMed).

Labrecque, Royal, Surprenant et al.: "Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 334-47, 2003 (PubMed).

Maggi, Biedi, Segat et al.: "IGF-I induces caveolin 1 tyrosine phosphorylation and translocation in the lipid rafts." in: Biochemical and biophysical research communications, Vol. 295, Issue 5, pp. 1085-9, 2002 (PubMed).