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MAP2K6 antibody (AA 205-209)

MAP2K6 Reactivity: Human WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN197355
  • Target See all MAP2K6 Antibodies
    MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
    Binding Specificity
    • 19
    • 15
    • 11
    • 9
    • 9
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 205-209
    Reactivity
    • 74
    • 63
    • 39
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 88
    • 6
    • 2
    Rabbit
    Clonality
    • 90
    • 6
    Polyclonal
    Conjugate
    • 47
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This MAP2K6 antibody is un-conjugated
    Application
    • 83
    • 41
    • 27
    • 27
    • 16
    • 14
    • 13
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    This antibody AP02676PU detects endogenous levels of total MKK6 protein.
    Purification
    Immunoaffinity Chromatography using epitope-specific immunogen.
    Immunogen
    Peptide sequence around amino acids 205~209 (V-D-S-V-A) derived from Human MKK6.
    Top Product
    Discover our top product MAP2K6 Primary Antibody
  • Application Notes
    Western blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at -20 °C.
  • Target
    MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
    Alternative Name
    MAP2K6 (MAP2K6 Products)
    Synonyms
    MAPKK6 antibody, MEK6 antibody, MKK6 antibody, PRKMK6 antibody, SAPKK-3 antibody, SAPKK3 antibody, Mkk6 antibody, Prkmk6 antibody, MKK3 antibody, map2k3 antibody, zMKK3 antibody, map2k6 antibody, mitogen-activated protein kinase kinase 6 antibody, mitogen-activated protein kinase kinase 6 L homeolog antibody, MAP2K6 antibody, Map2k6 antibody, map2k6 antibody, map2k6.L antibody
    Background
    Mitogen activated protein kinase kinase 6 (MEK6 or MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MEK6, closely related to MEK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38, thus activating it, in response to inflammatory cytokines and environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this protein is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.Synonyms: Dual specificity mitogen-activated protein kinase kinase 6, MAP kinase kinase 6, MAPK/ERK kinase 6, MAPKK 6, MEK6, MKK6, SAPKK3
    Gene ID
    5608
    NCBI Accession
    NP_002749
    UniProt
    P52564
    Pathways
    MAPK Signaling, TLR Signaling, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades
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