Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 205-209) antibody

Details for Product No. ABIN197355
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Antigen
Synonyms MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3, Mkk6, Prkmk6, ANQ1, ARABIDOPSIS NQK1, ARABIDOPSIS THALIANA MAP KINASE KINASE 6, ATMKK6, MAP kinase kinase 6, MIK19.2, MIK19_2, MKK3, map2k3, zMKK3
Epitope
AA 205-209
(38), (20), (13), (8), (7), (7), (5), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(150), (91), (82), (12), (12), (12), (1), (1)
Host
Rabbit
(132), (28), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(128), (70), (52), (31), (30), (23), (16), (9), (3), (2), (2), (1)
Pubmed 2 references available
Quantity 50 μg
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Catalog No. ABIN197355
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Immunogen Peptide sequence around amino acids 205~209 (V-D-S-V-A) derived from Human MKK6.
Specificity This antibody detects endogenous levels of total MKK6 protein.
Purification Immunoaffinity Chromatography using epitope-specific immunogen.
Alternative Name MAP2K6
Background Mitogen activated protein kinase kinase 6 (MEK6 or MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MEK6, closely related to MEK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38, thus activating it, in response to inflammatory cytokines and environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this protein is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
Alternate names: Dual specificity mitogen-activated protein kinase kinase 6, MAP kinase kinase 6, MAPK/ERK kinase 6, MAPKK 6, MEK6, MKK6, SAPKK3
Gene ID 5608
NCBI Accession NP_002749
UniProt P52564
Research Area Kinases/Phosphatases
Application Notes Western blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Supplier Images
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 205-209) antibody anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 205-209) antibody
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 205-209) antibody (2) anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 205-209) antibody (Image 2)
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 205-209) antibody (3) anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 205-209) antibody (Image 3)
Background publications Raingeaud, Whitmarsh, Barrett et al.: "MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway." in: Molecular and cellular biology, Vol. 16, Issue 3, pp. 1247-55, 1996 (PubMed).

Wang, Chen, Liao et al.: "Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3389-403, 2002 (PubMed).

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