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alpha Adducin antibody (Ser726)

ADD1 Reactivity: Human, Mouse, Rat WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN197406
  • Target See all alpha Adducin (ADD1) Antibodies
    alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))
    Binding Specificity
    • 17
    • 15
    • 15
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ser726
    Reactivity
    • 91
    • 55
    • 54
    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 90
    • 2
    Rabbit
    Clonality
    • 89
    • 2
    Polyclonal
    Conjugate
    • 57
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This alpha Adducin antibody is un-conjugated
    Application
    • 59
    • 36
    • 32
    • 28
    • 28
    • 25
    • 20
    • 16
    • 11
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    ADD1 antibody detects endogenous levels of total ADD1 protein.
    Purification
    Immunoaffinity chromatography
    Immunogen
    Synthetic non-phosphopeptide derived from human ADD1 around the phosphorylation site of serine 726 (T-P-Sp-F-L).
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    Discover our top product ADD1 Primary Antibody
  • Application Notes
    Suitable for use in in Western blot (1: 500-1: 1000).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at -20 °C.
  • Target
    alpha Adducin (ADD1) (Adducin 1 (Alpha) (ADD1))
    Alternative Name
    alpha-Adducin (ADD1) (ADD1 Products)
    Synonyms
    ADDA antibody, AI256389 antibody, alpha-adducin antibody, bZ1H20.1 antibody, cb787 antibody, zgc:158352 antibody, add2 antibody, adda antibody, add1-a antibody, ADD1 antibody, adducin 1 antibody, adducin 1 (alpha) antibody, adducin 1 S homeolog antibody, ADD1 antibody, Add1 antibody, add1 antibody, add1.S antibody
    Background
    Alpha adducin is a 80-120 kD member of the aldolase class II family and adducin subfamily. This protein has three isoforms that interact as heterodimers alpha/beta, and beta/gamma. The molecular weights for the various isoforms alpha=120 kD, beta=110kD, gamma=80kD. The alpha adducin protein is a ubiquitously expressed cytoskeletal protein that binds with high affinity to Ca2+/calmodulin and acts as a substrate for protein kinases A and C. This protein has been reported to promote the assembly of the spectrinactin network. Polymorphisms in alpha adducin are associated with cardiovascular disease and hypertension. Alpha adducin has been reported to interact with calmodulin. When phosphorylated by Rho-kinase, alpha adducin can regulate membrane ruffling and cell motility.Synonyms: ADDA, Erythrocyte adducin subunit alpha
    Gene ID
    118
    NCBI Accession
    NP_001110
    UniProt
    P35611
    Pathways
    Negative Regulation of Hormone Secretion, Regulation of Actin Filament Polymerization, Regulation of Lipid Metabolism by PPARalpha, ER-Nucleus Signaling
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