BICC1 antibody (Bicaudal C Homolog 1 (Drosophila)) (AA 80-107)

Details for Product anti-BICC1 Antibody No. ABIN1981375, Supplier: Log in to see
Antigen
  • bicc1
  • xBic-C
  • x-Bic-C
  • Bicaudal-C
  • BICC
  • CYSRD
  • Bic-C
  • bpk
  • jcpk
  • bicaudal C homolog 1 (Drosophila)
  • bicaudal C homolog 1b (Drosophila)
  • bicaudal C homolog 1
  • BICC1
  • bicc1b
  • bicc1
  • Bicc1
Epitope
AA 80-107, N-Term
25
20
4
3
3
1
Reactivity
Human
54
6
4
3
2
2
2
2
2
1
1
Host
Rabbit
29
25
Clonality
Polyclonal
Conjugate
This BICC1 antibody is un-conjugated
4
4
4
4
4
4
Application
Immunohistochemistry (IHC), Western Blotting (WB)
37
31
10
5
3
2
1
1
Options
Supplier
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Purpose Polyclonal Antibody to detect BICC1 in human samples
Immunogen This BICC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 AA from the N-terminal region of human BICC1.
Isotype IgG
Specificity Polyclonal Antibody detects BICC1 in human samples
Characteristics Polyclonal Antibody to detect BICC1 in human samples
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name BICC1 (BICC1 Antibody Abstract)
Background BICC1, also known as protein bicaudal C homolog 1, is a 974 amino acid protein that belongs to the BICC family. BICC1 is considered a putative RNA-binding protein and may be involved in regulating gene expression during embryonic development by modulating protein translation. Existing as two alternatively spliced isoforms, BICC1 contains two KH domains as well as one SAM (sterile α motif) domain. Both BICC1 isoforms are widely expressed in normal tissues and are found in all brain regions including cerebral cortex, hippocampus and midbrain, although BICC1 isoform 1 is more highly expressed than isoform 2, particularly in nerve tissue. BICC1 can uncouple dishevelled-2 (Dvl-2) signaling from the canonical Wnt pathway in a SAM domain dependent manner, suggesting that the different BICC1 isoforms may play varying biological roles. Genetic variants in BICC1 may be involved in recurrent unipolar major depression. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.
Synonyms: BICC1, Protein bicaudal C homolog 1
Gene ID 80114
UniProt Q9H694
Application Notes Western blot: ~1:1000, IHC: ~1:10-1:50.
Comment

Suggested positive control:
Western blot: HL60 cell lysate, IHC: human brain tissue

Restrictions For Research Use only
Format Liquid
Buffer 100 μL of antibody in PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Storage -20 °C
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Bicaudal C Homolog 1 (Drosophila) (BICC1) (AA 80-107), (N-Term) antibody (ABIN1981375) anti-Bicaudal C Homolog 1 (Drosophila) (BICC1) (AA 80-107), (N-Term) antibody
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