COL4A1 antibody (AA 30-167) (FITC)

Catalog No. ABIN1991869

Product Details anti-COL4A1 Antibody (FITC)

Target: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Binding Specificity: AA 30-167

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COL4A1 antibody is conjugated to FITC

Application: ELISA, Western Blotting (WB)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Collagen alpha-1(IV) chain protein (30-167AA)

Isotype: IgG

Application Details

Application Notes: Optimal working concentration should be determinde by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for COL4A1

Target: COL4A1 (Collagen, Type IV, alpha 1 (COL4A1))

Alternative Name: COL4A1 (COL4A1 Products)

Synonyms: col4a1 antibody, wu:fc02g11 antibody, HANAC antibody, ICH antibody, POREN1 antibody, arresten antibody, Bru antibody, Col4a-1 antibody, Del(8)44H antibody, Raw antibody, Svc antibody, collagen, type IV, alpha 5 (Alport syndrome) antibody, collagen type IV alpha 1 chain antibody, collagen, type IV, alpha 1 antibody, col4a5 antibody, COL4A1 antibody, Col4a1 antibody

Background:

Background: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a \'chicken-wire\' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.

Aliases: Arresten antibody, BSVD antibody, CO4A1_HUMAN antibody, COL4A1 antibody, COL4A1 NC1 domain antibody, COL4A2 antibody, COL4A3 antibody, COL4A4 antibody, COL4A5 antibody, collagen alpha-1(IV) chain antibody, Collagen IV Alpha 1 Polypeptide antibody, Collagen IV Alpha 2 Polypeptide antibody, Collagen Of Basement Membrane Alpha 1 Chain antibody, Collagen Of Basement Membrane Alpha 2 Chain antibody, Collagen Type IV Alpha 1 antibody, collagen type IV alpha 1 chain antibody, Collagen Type IV Alpha 2 antibody, Collagen Type IV Alpha 3 antibody, Collagen Type IV Alpha 4 antibody, Collagen Type IV Alpha 5 antibody, RATOR antibody

UniProt: P02462

Pathways: Skeletal Muscle Fiber Development, Growth Factor Binding