Fetuin A antibody (alpha-2-HS-Glycoprotein) (AA 1-367)

Details for Product anti-AHSG Antibody No. ABIN1996377, Supplier: Log in to see
Antigen
  • ahs
  • a2hs
  • hsga
  • fetua
  • wu:fb63g02
  • zgc:103687
  • AHSG
  • MGC116429
  • A2HS
  • AHS
  • FETUA
  • HSGA
  • Aa2-066
  • pp63
  • alpha-2-HS-glycoprotein
  • FETUIN protein
  • Cphamn1_1981
  • AHSG
  • ahsg
  • Ahsg
  • FETUIN
Epitope
AA 1-367
15
15
14
14
12
10
8
8
7
5
5
3
2
2
2
1
1
1
1
Reactivity
Human
167
53
29
7
2
2
2
1
1
Host
Rabbit
127
25
24
18
15
3
Clonality (Clone)
Monoclonal ()
Conjugate
This Fetuin A antibody is un-conjugated
15
13
8
6
6
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA, ELISA (Detection), Immunofluorescence (IF), Immunofluorescence (fixed cells) (IF/ICC)
151
101
60
33
30
25
19
16
13
11
6
2
1
1
1
1
1
1
1
Options
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Immunogen Recombinant Human Fetuin-A protein (ABIN2002562)
Clone 1
Isotype IgG
Specificity Human Fetuin-A / AHSG
No cross-reactivity in ELISA with
Human Cystatin-C
Human Cystatin-E
Mouse Fetain-A
No Cross-Reactivity Human, Mouse (Murine)
Characteristics This antibody was obtained from a rabbit immunized with purified, recombinant Human Fetuin-A / AHSG (rh Fetuin-A, ABIN2002562 NP_001613.2, Met 1-Val 367, .
Sterility 0.2 μm filtered
Alternative Name AHSG (AHSG Antibody Abstract)
Background Human Fetuin-A, also known as α2-Heremans-Schmid glycoprotein (AHSG), is a member of cystatin superfamily of protease inhibitors. It is expressed and secreted mainly by the cell source hepatocytes, and can be found at high levels in the serum as a growth promoter. As an antagonist of transforming growth factor-beta1 (TGF-β1), fetuin-A blocks TGF-beta1 binding to cell surface receptors, suppresses TGF-beta signal transduction and epithelial- mesenchymal transition, suggesting that the systemic fetuin A is closely associated with tumor progression and resistance to chemotherapy in established cancers, as well as host immune suppression. Accordingly, therapeutic enhancement of AHSG levels may benefit patients whose tumors are driven by TGF-beta. It has been shown that fetuin A inhibits both insulin receptor autophosphorylation and undesirable calcification, and plays a role in bone development, calcium homeostasis, regulation of soft tissue calcification, and insulin sensitivity.
NCBI Accession NP_001613.2
Application Notes ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human Fetuin-A. The detection limit for Human FetuinA is 0.00975 ng/well.
ELISA(Det): 0.1-1 μg/mL
ICC/IF: 10-25 μg/mL
Restrictions For Research Use only
Format Liquid
Buffer 0.2 μm filtered solution in PBS
Preservative Without preservative
Handling Advice Avoid repeated freeze-thaw cycles.
Storage 4 °C,-20 °C,-80 °C
Storage Comment This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Expiry Date 12 months
Supplier Images
Immunofluorescence (IF) image for anti-Fetuin A antibody (alpha-2-HS-Glycoprotein) (AA 1-367) (ABIN1996377) anti-alpha-2-HS-Glycoprotein (AHSG) (AA 1-367) antibody
Immunofluorescence (IF) image for anti-Fetuin A antibody (alpha-2-HS-Glycoprotein) (AA 1-367) (ABIN1996377) Immunofluorescence staining of Human ADAM15 in Hela cells. Cells were fixed with 4% P...
Product cited in: Zheng, Li, Zhang, Zhou, Ma, Zhou, Chen, Lin: "Salivary biomarkers indicate obstructive sleep apnea patients with cardiovascular diseases." in: Scientific reports, Vol. 4, pp. 7046, 2014 (PubMed).