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PRDM1 antibody (C-Term)

PRDM1 Reactivity: Human Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2017609
  • Target See all PRDM1 Antibodies
    PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))
    Binding Specificity
    • 8
    • 7
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 62
    • 18
    • 12
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 41
    • 23
    • 3
    Rabbit
    Clonality
    • 46
    • 21
    Polyclonal
    Conjugate
    • 45
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PRDM1 antibody is un-conjugated
    Application
    Please inquire
    Specificity
    Blimp-1 Antibody, pAb, Rabbit detects endogenous levels of human Blimp-1.
    Cross-Reactivity (Details)
    It is predicted to react with mouse Blimp-1 according to sequence homology.
    Reactivity to other species is not tested yet.
    Characteristics
    Blimp-1 Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide from C-terminal of human Blimp-1 (Swiss Prot: O75626).
    Purification
    Immunoaffinity chromatography
    Immunogen
    KLH-coupled synthetic peptide from C-terminal of human Blimp-1
    Isotype
    IgG
    Top Product
    Discover our top product PRDM1 Primary Antibody
  • Comment

    Positive Control: K562, Ramos

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute the lyophilized powder with deionized water (or equivalent) to an antibody concentration of 0.5 mg/mL.
    Concentration
    0.5 mg/mL
    Buffer
    Lyophilized with PBS, pH 7.4, containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    The antibody is stable in lyophilized form if stored at -20°C or below. The reconstituted antibody can be stored for 2-3 weeks at 2-8°C. For long term storage, aliquot and store at -20°C or below.
  • Chou, Pinto, Curtis, Persaud, Cella, Lin, Edelson, Allen, Colonna, Pearce, Diamond, Egawa: "c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells." in: Nature immunology, Vol. 15, Issue 9, pp. 884-93, (2014) (PubMed).

    Oestreich, Mohn, Weinmann: "Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile." in: Nature immunology, Vol. 13, Issue 4, pp. 405-11, (2012) (PubMed).

  • Target
    PRDM1 (PR Domain Containing 1, with ZNF Domain (PRDM1))
    Alternative Name
    Blimp-1 (PRDM1 Products)
    Synonyms
    GB11750 antibody, CG5249 antibody, Dmel\\CG5249 antibody, blimp-1 antibody, dBlimp-1 antibody, dBlimp1 antibody, Blimp-1 antibody, Blimp1 antibody, nrd antibody, prdm1 antibody, ubo antibody, wu:fb99c12 antibody, zgc:91885 antibody, MGC52536 antibody, PRDM1 antibody, blimp1 antibody, xblimp1 antibody, prdi-bf1 antibody, BLIMP1 antibody, PRDI-BF1 antibody, ZNFPR1A1 antibody, PR/SET domain 1 antibody, probable serine/threonine-protein kinase DDB_G0282963 antibody, CG5249 gene product from transcript CG5249-RF antibody, blimp-1 antibody, PR domain containing 1a, with ZNF domain antibody, PR domain 1 S homeolog antibody, B lymphocyte induced maturation protein 1 antibody, PR domain 1 antibody, PR domain containing 1, with ZNF domain antibody, PRDM1 antibody, LOC408295 antibody, Blimp-1 antibody, CpipJ_CPIJ007425 antibody, prdm1a antibody, prdm1.S antibody, prdm1 antibody, Prdm1 antibody
    Background
    Blimp-1 (B lymphocyte-induced maturation protein) is a nuclear zinc-finger containing transcriptional repressor and plays an important role in terminal B-cell development. Expression of Blimp-1 is sufficient to drive terminal differentiation of BCL1 lymphoma cells into antibody secreting plasma cells, increasing the expression of the cell surface marker Syndecan-1. In addition, Blimp-1 has been found during macrophage differentiation and in a subset of T-cells, which suggests that it may play a wider role in homeostasis and differentiation.
    UniProt
    O75626
    Pathways
    Regulation of Muscle Cell Differentiation
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