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KDM5A antibody (AA 101-200) (HRP)

KDM5A Reactivity: Human WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal HRP
Catalog No. ABIN2177132
  • Target See all KDM5A Antibodies
    KDM5A (Lysine (K)-Specific Demethylase 5A (KDM5A))
    Binding Specificity
    • 14
    • 9
    • 8
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 101-200
    Reactivity
    • 68
    • 15
    • 4
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 61
    • 6
    Rabbit
    Clonality
    • 54
    • 14
    Polyclonal
    Conjugate
    • 27
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This KDM5A antibody is conjugated to HRP
    Application
    • 47
    • 24
    • 17
    • 14
    • 13
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human KDM5A
    Isotype
    IgG
    Top Product
    Discover our top product KDM5A Primary Antibody
  • Application Notes
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    KDM5A (Lysine (K)-Specific Demethylase 5A (KDM5A))
    Alternative Name
    KDM5A (KDM5A Products)
    Synonyms
    Jarid1a antibody, JARID1A antibody, RBBP-2 antibody, RBBP2 antibody, RBP2 antibody, AA409370 antibody, C76986 antibody, Rbbp2 antibody, lysine demethylase 5A antibody, lysine (K)-specific demethylase 5A antibody, Kdm5a antibody, KDM5A antibody
    Background

    Synonyms: RBP2, RBBP2, RBBP-2, Lysine-specific demethylase 5A, Histone demethylase JARID1A, Jumonji/ARID domain-containing protein 1A, Retinoblastoma-binding protein 2, KDM5A, JARID1A

    Background: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).

    Gene ID
    5927
    UniProt
    P29375
    Pathways
    Chromatin Binding, Warburg Effect
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