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TWIST1, TWIST2 (AA 71-170) antibody

Reactivity: Human, Mouse, Rat IF (cc), IF (p), WB, IHC (p), ELISA, IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2179882
  • Target
    TWIST1, TWIST2
    Binding Specificity
    • 15
    • 14
    AA 71-170
    Reactivity
    Human, Mouse, Rat
    Host
    • 30
    Rabbit
    Clonality
    • 30
    Polyclonal
    Conjugate
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Un-conjugated
    Application
    • 25
    • 25
    • 15
    • 6
    • 5
    • 5
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    This antibody will detect TWIST1 and TWIST2
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TWIST1
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    TWIST1, TWIST2
    Alternative Name
    TWIST1 and TWIST2
    Synonyms
    Twist antibody, DERMO1 antibody, FFDD3 antibody, SETLSS antibody, bHLHa39 antibody, AA960487 antibody, M-Twist antibody, Pde antibody, Ska10 antibody, Ska antibody, bHLHa38 antibody, pdt antibody, FDXP2 antibody, twist family bHLH transcription factor 1 antibody, twist family bHLH transcription factor 2 antibody, twist basic helix-loop-helix transcription factor 1 antibody, ferredoxin 1 pseudogene 2 antibody, Twist1 antibody, TWIST2 antibody, FDX1P2 antibody
    Background

    Synonyms: TWIST, bHLHa38, Twist-related protein 1, Class A basic helix-loop-helix protein 38, H-twist, TWIST1, bHLHa39, Class A basic helix-loop-helix protein 39, Dermis expressed protein 1, Dermis-expressed protein 1, DERMO 1, Dermo-1, DERMO1, MGC117334, Twist 2, Twist homolog 2 Drosophila, Twist homolog 2, Twist related bHLH protein Dermo1, Twist related protein 2, Twist-related protein 2, Twist2, TWST2_HUMAN.

    Background: TWIST1 and TWIST2 are basic helix-loop-helix transcriptional repressors that bind to E boxes in gene promoters, acting as master regulators in a variety of biological processes, including organogenesis, osteogenesis, cancer progression and hematopoietic cell development. Both TWIST1 and TWIST2 are found to act as Homodimers or Heterodimers with another bHLH protein. TWIST1 Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses expression of proinflammatory cytokines such as TNFA and IL1B. TWIST2 inhibits transcriptional activation by MYOD1, MYOG, MEF2A, and MEF2C. Twist2 inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis.

    Gene ID
    7291, 117581
    UniProt
    Q15672, Q8WVJ9
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