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beta 2 Adrenergic Receptor antibody

ADRB2 Reactivity: Human FACS, Func, IA Host: Mouse Monoclonal 6H8 unconjugated
Catalog No. ABIN2192080
  • Target See all beta 2 Adrenergic Receptor (ADRB2) Antibodies
    beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))
    Reactivity
    • 150
    • 78
    • 69
    • 8
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 149
    • 9
    • 2
    • 1
    • 1
    Mouse
    Clonality
    • 137
    • 23
    • 2
    Monoclonal
    Conjugate
    • 84
    • 12
    • 10
    • 10
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    This beta 2 Adrenergic Receptor antibody is un-conjugated
    Application
    • 111
    • 72
    • 49
    • 40
    • 27
    • 26
    • 26
    • 22
    • 15
    • 13
    • 10
    • 7
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func), Immunoassay (IA)
    Cross-Reactivity (Details)
    Cross reactivity: Rat : Yes, Guinea Pig : Yes
    Sterility
    0.2 μm filtered
    Clone
    6H8
    Isotype
    IgG1
    Top Product
    Discover our top product ADRB2 Primary Antibody
  • Application Notes
    For flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive Human epidermoid carcinoma cell A431 line control
    Restrictions
    For Research Use only
  • Buffer
    PBS, containing 0.1 % bovine serum albumin
    Storage
    4 °C
    Storage Comment
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Mijares, Lebesgue, Wallukat, Hoebeke: "From agonist to antagonist: Fab fragments of an agonist-like monoclonal anti-beta(2)-adrenoceptor antibody behave as antagonists." in: Molecular pharmacology, Vol. 58, Issue 2, pp. 373-9, (2000) (PubMed).

    Lebesgue, Wallukat, Mijares, Granier, Argibay, Hoebeke: "An agonist-like monoclonal antibody against the human beta2-adrenoceptor." in: European journal of pharmacology, Vol. 348, Issue 1, pp. 123-33, (1998) (PubMed).

  • Target
    beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))
    Alternative Name
    Beta2-Adrenoceptor (ADRB2 Products)
    Synonyms
    zgc:162188 antibody, adrb2 antibody, Adrb-2 antibody, Badm antibody, Gpcr7 antibody, ADRB2R antibody, ADRBR antibody, B2AR antibody, BAR antibody, BETA2AR antibody, adrenoceptor beta 2 antibody, adrenoceptor beta 2, surface b antibody, beta2-adrenergic receptor antibody, adrenergic receptor, beta 2 antibody, ADRB2 antibody, adrb2b antibody, LOC100136153 antibody, Adrb2 antibody
    Background
    The monoclonal antibody 6H8 recognizes human beta2-adrenoceptor. The b -adrenoceptors can be divided into b1, b2, b3 and b4-adrenoceptors defined in terms of agonist potencies, b2-adrenoceptors displayed a higher selectivity for nor-adrenaline than for adrenaline. B2-receptors are mainly postsynaptic and are located on a number of tissues including blood vessels, bronchi, GIT, skeletal muscle, liver and mast cell. Activation results in vasodilatation, bronchodilation, relaxation of the GIT, glycogenolysis in the liver, tremor in skeletal muscle and inhibition of histamine release from mast cells. Transduction is via G-proteins coupled to the intracellular second messenger adenylate cyclase. B- receptors are positively coupled to adenylate cyclase via activation of Gs G-protein, however activation of the b2-adrenoceptors results in stimulation and inhibition of adenylate cyclase. The b2- receptor selective agonists are widely used in the treatment of asthma and other related bronchospastic conditions. They are commonly used in the treatment of angina pectoris, cardiac arrhythmia and for the long-term treatment of patients who survive myocardial infarction. B-receptor antagonists have also been used as anti-hypertensive for a number of years. Beta -blockers have also proven useful in the treatment of conditions such as migraine, anxiety disorders, hyperthyroidism, alcohol withdrawal and when applied topically are useful in the treatment of glaucoma and ocular hypertension. Immunogen Free peptide Beta2-H19C
    Pathways
    cAMP Metabolic Process, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Brown Fat Cell Differentiation
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