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Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) antibody

Details for Product No. ABIN222869
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Antigen
Synonyms
CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRICE, Dmel\\CG7788, DrICE, DrIce, Dric ... show more
CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRICE, Dmel\\CG7788, DrICE, DrIce, Drice, ICE, crice, drICE, drIce, drice, ice, A830040C14Rik, AC-3, Apopain, CPP32, Lice, Yama, mldy, CPP32B, SCA-1, xcpp32 show less
Reactivity
Human
(294), (116), (92), (18), (17), (17), (5), (5), (4), (4), (4), (3), (2), (2), (2), (1)
Host
Mouse
(271), (51), (7), (2), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (7), (5), (4), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(258), (113), (99), (91), (54), (31), (19), (19), (19), (14), (10), (4), (2), (2), (2)
Pubmed 7 references available
Quantity 100 µg
Options
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Request Want additional data for this product?

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Catalog No. ABIN222869
324.50 $
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Immunogen Recombinant human Caspase-3
Clone C33
Isotype IgG1
Specificity Detects both procaspase-3 and the cleaved fragments of active caspase-3 in human and mouse sample
Purification Affinity purified
Alternative Name Caspase-3
Background The caspase family of cysteine proteases play a key role in apoptosis. Caspase-3 is the most extensively studied apoptotic protein among caspase family members. Caspase-3 is synthesized as inactive pro-enzyme that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another upstream protease. The processed form of caspase-3 consists of large (17 kD) and small (12 kD) subunits which associate to form an active enzyme. The active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cells (e.g., PARP and DFF).
Gene ID 836
Research Area Apoptosis/Necrosis, Autophagy
Application Notes Western blotting (0.5-4 µg/mL).
However the optimal conditions should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS containing 50 % glycerol, 0.5 mg/mL BSA and 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) antibody Western blot analysis of caspase-3 expression in HeLa cells treated with camptothecin (2 um)
Product cited in: Ahmed, Alcock, Chendil et al.: "Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2." in: The Journal of biological chemistry, Vol. 277, Issue 3, pp. 2234-46, 2002 (PubMed).

Atkin, Farg, Turner et al.: "Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1." in: The Journal of biological chemistry, Vol. 281, Issue 40, pp. 30152-65, 2006 (PubMed).

Pietri, Caprini, Mouillet-Richard et al.: "Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells." in: The Journal of biological chemistry, Vol. 281, Issue 38, pp. 28470-9, 2006 (PubMed).

Chiou, Hodges, Hoa: "Suppression of growth arrest and DNA damage-inducible 45alpha expression confers resistance to sulindac and indomethacin-induced gastric mucosal injury." in: The Journal of pharmacology and experimental therapeutics, Vol. 334, Issue 3, pp. 693-702, 2010 (PubMed).

Anand, Wilson, Hasan et al.: "Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy." in: Cancer research, Vol. 71, Issue 18, pp. 6040-50, 2011 (PubMed).

Schwartz, Barker, Kaufman et al.: "Francisella tularensis inhibits the intrinsic and extrinsic pathways to delay constitutive apoptosis and prolong human neutrophil lifespan." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 7, pp. 3351-63, 2012 (PubMed).

General El Golli Bennour, Rodriguez-Enfedaque, Bouaziz et al.: "Toxicities induced in cultured human hepatocarcinoma cells exposed to ochratoxin A: oxidative stress and apoptosis status." in: Journal of biochemical and molecular toxicology, Vol. 23, Issue 2, pp. 87-96, 2009 (PubMed).

Validation Images
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