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Caspase 3 antibody (Caspase 3, Apoptosis-Related Cysteine Peptidase) (Cleavage Site)

Details for Product anti-CASP3 Antibody No. ABIN222873, Supplier: Login to see New
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CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRICE, Dmel\\CG7788, DrICE, DrIce, Dric ... show more
CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRICE, Dmel\\CG7788, DrICE, DrIce, Drice, ICE, crice, drICE, drIce, drice, ice, A830040C14Rik, AC-3, Apopain, CPP32, Lice, Yama, mldy, CPP32B, SCA-1, xcpp32 show less
Cleavage Site, N-Term, active
(40), (31), (31), (30), (22), (21), (19), (19), (14), (13), (13), (13), (12), (10), (10), (9), (7), (6), (6), (5), (5), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(483), (190), (139), (26), (17), (13), (13), (13), (12), (9), (6), (5), (5), (4), (3), (2), (1)
(465), (78), (16), (3), (2)
Biological Activity Active
This Caspase 3 antibody is un-conjugated
(26), (21), (17), (10), (9), (9), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(399), (204), (165), (114), (71), (59), (39), (32), (30), (23), (22), (10), (7), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 21 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide mapping to the N-terminus adjacent to the cleavage site of human caspase-3
Blocking Peptide Blocking peptide for this product available: ABIN412650
Isotype IgG
Specificity Preferentially recognizes active human/mouse/rat caspase-3 (p20 subunits) and does not detect the precursor form
Purification Affinity purified
Alternative Name Caspase-3 (CASP3 Antibody Abstract)
Background Caspase-3 has been extensively studied and implicated to play an important role in apoptosis. Active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cells (e.g., PARP). The affinity purified antibody recognizing the active forms of caspase-3 provides a new tool for identifying apoptotic cell populations in both tissue sections and cultured cells.
Synonyms: CPP32 ,CASP3, apopain, procaspase3,CPP32B,SCA-1,CPP-32,Apopain,Yama
Gene ID 836
UniProt P42574
Research Area Apoptosis/Necrosis, Autophagy
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Western blotting (1:50 -1:500 dilutions) and Immunohistochemistry (1:10-1:20 dilutions).
However, the optimal concentrations should be determined individually.

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 500 μL antigen affinity purified rabbit anti-Active Caspase-3 antibody in phosphate-buffered saline (PBS) containing 50 % glycerol, 1 % BSA, and 0.02 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Caspase 3 antibody (Caspase 3, Apoptosis-Related Cysteine Peptidase) (Cleavage Site) (ABIN222873) Western blot analysis of caspase-3 in camptothecin (2 uM) treated Jurkat cells
Product cited in: Zahavi, Ionescu, Gluska et al.: "A compartmentalized microfluidic neuromuscular co-culture system reveals spatial aspects of GDNF functions." in: Journal of cell science, Vol. 128, Issue 6, pp. 1241-52, 2015 (PubMed).

Wang, Lauer, Anand et al.: "Hyaluronan synthase 2 protects skin fibroblasts against apoptosis induced by environmental stress." in: The Journal of biological chemistry, Vol. 289, Issue 46, pp. 32253-65, 2014 (PubMed).

Anjum, Krishna, Tsutsui: "Inhibitory roles of the mammalian GnIH ortholog RFRP3 in testicular activities in adult mice." in: The Journal of endocrinology, Vol. 223, Issue 1, pp. 79-91, 2014 (PubMed).

Greenlee-Wacker, Rigby, Kobayashi et al.: "Phagocytosis of Staphylococcus aureus by human neutrophils prevents macrophage efferocytosis and induces programmed necrosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 10, pp. 4709-17, 2014 (PubMed).

Eslami, Sharifi, Rahimi et al.: "Protective effect of telmisartan against oxidative damage induced by high glucose in neuronal PC12 cell." in: Neuroscience letters, 2013 (PubMed).

Sun, Li, He et al.: "Neuroprotective effect of minocycline in a rat model of branch retinal vein occlusion." in: Experimental eye research, Vol. 113, pp. 105-16, 2013 (PubMed).

Finnie, Blumbergs, Manavis: "Aquaporin-4 expression after experimental contusional injury in an ovine impact-acceleration head injury model." in: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, Vol. 18, Issue 7, pp. 947-50, 2011 (PubMed).

Wu, Chen, Yen et al.: "Neuroprotection by the Traditional Chinese Medicine, Tao-Hong-Si-Wu-Tang, against Middle Cerebral Artery Occlusion-Induced Cerebral Ischemia in Rats." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2011, pp. 803015, 2010 (PubMed).

Krejbich-Trotot, Denizot, Hoarau et al.: "Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses." in: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 25, Issue 1, pp. 314-25, 2011 (PubMed).

Maher, Evans, Bottoms et al.: "Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis." in: American journal of respiratory and critical care medicine, Vol. 182, Issue 1, pp. 73-82, 2010 (PubMed).

Ueda, Ueyama, Oka et al.: "Polaprezinc (Zinc L-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1 - a new mechanism of gastric mucosal protection." in: Journal of pharmacological sciences, Vol. 110, Issue 3, pp. 285-94, 2009 (PubMed).

Roy, Krishna: "Evidence of androgen-dependent sperm storage in female reproductive tract of Scotophilus heathi." in: General and comparative endocrinology, Vol. 165, Issue 1, pp. 120-6, 2009 (PubMed).

Rabin, Flitton, Demuth: "Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces apoptosis in nonproliferating macrophages by a phosphatase-independent mechanism." in: Infection and immunity, Vol. 77, Issue 8, pp. 3161-9, 2009 (PubMed).

Chang, Hsieh, Peng et al.: "Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats." in: Journal of biomedical science, Vol. 16, pp. 9, 2009 (PubMed).

Ou, Lee, Lee et al.: "Ginkgo biloba extract attenuates oxLDL-induced oxidative functional damages in endothelial cells." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 106, Issue 5, pp. 1674-85, 2009 (PubMed).

Mendoza-Rodruiguez, Martuinez, Vargas et al.: "Mating modifies apoptosis pattern in epithelial cells of the rat uterus." in: Molecular reproduction and development, Vol. 76, Issue 6, pp. 564-72, 2009 (PubMed).

Guo, Tang, Li et al.: "[The analysis of the treatment of giant cell tumor of the pelvis and sacrum]" in: Zhonghua wai ke za zhi [Chinese journal of surgery], Vol. 46, Issue 7, pp. 501-5, 2008 (PubMed).

Frost, Zhou, Krasnesky et al.: "Initiation of oligodendrocyte progenitor cell migration by a PDGF-A activated extracellular regulated kinase (ERK) signaling pathway." in: Neurochemical research, Vol. 34, Issue 1, pp. 169-81, 2009 (PubMed).

Schmidt, Paes, De Mazière et al.: "EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution." in: Development (Cambridge, England), Vol. 134, Issue 16, pp. 2913-23, 2007 (PubMed).

Wang, Ladrech, Pujol et al.: "Caspase inhibitors, but not c-Jun NH2-terminal kinase inhibitor treatment, prevent cisplatin-induced hearing loss." in: Cancer research, Vol. 64, Issue 24, pp. 9217-24, 2004 (PubMed).

Li, Zhang, Soledad-Conrad et al.: "Bleomycin-induced apoptosis of alveolar epithelial cells requires angiotensin synthesis de novo." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 284, Issue 3, pp. L501-7, 2003 (PubMed).

Catalog No. ABIN222873
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