Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody

Details for Product No. ABIN222874
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Antigen
Synonyms APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56, AI115399, AW493809, CASP-9, Caspase-9, Mch6, Apaf3, Casp9_v1, Ice-Lap6, Casp-9-CTD, CASP9
Reactivity
Human, Mouse (Murine), Rat (Rattus), Hamster, Monkey, Rabbit, Dog (Canine), Pig (Porcine), Cow (Bovine)
(298), (107), (93), (16), (14), (9), (6), (5), (2), (2), (1)
Host
Rabbit
(306), (30), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application
Western Blotting (WB)
(284), (130), (69), (63), (51), (50), (39), (36), (10), (4), (3), (2), (1)
Pubmed 3 references available
Catalog no. ABIN222874
Quantity 100 µg
Price
291.50 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide surrounding AA 290 of human caspase-9
Isotype IgG
Specificity Detects procaspase-9 and the cleavage fragment of active caspase-9
Purification Affinity purified
Alternative Name Caspase-9
Background Caspase-9 is one of the most important caspases among the caspase family members. Caspase-9 is synthesized as inactive pro-enzyme that is processed in cells undergoing apoptosis. The processed caspase-9 consists of large (32-35 kD) and small (10 kD) subunits which associate to form an active enzyme. Activated caspase-9 in turn cleaves and activates caspase-3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis.
Gene ID 842
Research Area Apoptosis/Necrosis, Cancer
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL).
However the optimal conditions should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody Western blot analysis of Caspase 9with rat kidney tissue lysate.
Product cited in: Siu, Alway: "Mitochondria-associated apoptotic signalling in denervated rat skeletal muscle." in: The Journal of physiology, Vol. 565, Issue Pt 1, pp. 309-23, 2005 (PubMed).

Takebe, Cheng, Fandy et al.: "IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells." in: Molecular cancer therapeutics, Vol. 5, Issue 2, pp. 457-66, 2006 (PubMed).

Woods, Burns, Bradford et al.: "WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 98, Issue 2, pp. 366-74, 2007 (PubMed).

Hosts (306), (30), (1)
Reactivities (298), (107), (93), (16), (14), (9), (6), (5), (2), (2), (1)
Applications (284), (130), (69), (63), (51), (50), (39), (36), (10), (4), (3), (2), (1)
Conjugates (9), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Epitopes (25), (22), (18), (15), (13), (9), (7), (5), (5), (5), (5), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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