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Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody

Antigen

Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9)
Synonyms MCH6, APAF3, APAF-3, ICE-LAP6, CASPASE-9c, Mch6, AI115399, AW493809, Caspase-9, CASP9, LOC100101592
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human, Mouse (Murine), Rat (Rattus), Hamster, Monkey, Rabbit, Dog (Canine), Pig (Porcine), Cow (Bovine)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
3 references available
Catalog no. ABIN222874
Quantity 100 ug  (0.2 mg/mL)  (Variants)
Price 291.50 $   Plus shipping costs $45.00
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anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody

Additional Information
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Alternative name Caspase-9
Gene ID 842
Immunogen Synthetic peptide surrounding amino acid 290 of human caspase-9
Format Liquid
Isotype IgG
Description Caspase-9 is one of the most important caspases among the caspase family members. Caspase-9 is synthesized as inactive pro-enzyme that is processed in cells undergoing apoptosis. The processed caspase-9 consists of large (32-35 kD) and small (10 kD) subunits which associate to form an active enzyme. Activated caspase-9 in turn cleaves and activates caspase-3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis.
Specificity Detects procaspase-9 and the cleavage fragment of active caspase-9

Application Details
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Application Notes The antibody can be used for Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. Blocking peptide is available separately .
Handling Advice The antibody solution should be gently mixed before use.
Concentration 0.2 mg/mL
Purification Affinity purified
Buffer phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Preservative Thimerosal
Storage -20 °C
Expiry Date 12 months
Research Area Apoptosis/Necrosis
Restrictions For Research Use only

Publications
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Product Siu, Alway: "Mitochondria-associated apoptotic signalling in denervated rat skeletal muscle." in: The Journal of physiology, Vol. 565, Issue Pt 1, pp. 309-23, 2005 (PubMed).

Takebe, Cheng, Fandy et al.: "IMP dehydrogenase inhibitor mycophenolate mofetil induces caspase-dependent apoptosis and cell cycle inhibition in multiple myeloma cells." in: Molecular cancer therapeutics, Vol. 5, Issue 2, pp. 457-66, 2006 (PubMed).

Woods, Burns, Bradford et al.: "WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase." in: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 98, Issue 2, pp. 366-74, 2007 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9)", type "Antibodies"
Hosts Rabbit (245), Mouse (16), Goat (1)
Reactivities Human (244), Rat (Rattus) (110), Mouse (Murine) (89), Dog (Canine) (23), Cow (Bovine) (22), Hamster (3), Monkey (3), Gerbil (2), Pig (Porcine) (2), Rabbit (2), Cat (Feline) (1), Chicken (1), Sheep (Ovine) (1)
Applications Western Blotting (WB) (179), Immunofluorescence (IF) (103), ELISA (74), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (61), Immunoprecipitation (IP) (41), Immunohistochemistry (IHC) (27), Immunocytochemistry (ICC) (20), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (15), Immunohistochemistry (Frozen Sections) (IHC (fro)) (7), Immunoelectron Microscopy (IEM) (6), Immunohistochemistry (Fixed) (IHC (fx)) (5), Flow Cytometry (FACS) (3)
Conjugates Biotin (8), Alexa Fluor 350 (5), Alexa Fluor 488 (5), Alexa Fluor 555 (5), Alexa Fluor 647 (5), Cy3 (5), Cy5 (5), Cy5.5 (5), Cy7 (5), FITC (5), Gold (5), HRP (5), PE (5), PE,Cy3 (5), PE,Cy5 (5), PE,Cy5.5 (5), PE,Cy7 (5)
Epitopes N-Term (26), C-Term (25), pSer196 (22), pThr125 (19), pTyr153 (19), Internal Region (12), AA 299-318 (7), AA 41-56 (5), active (4), pThr125,Internal Region (3), AA 112-130 (2), AA 188-206 (2), AA 301-305 (2), Asp315 (2), Asp353 (2), Center (2), Middle Region 2 (2), Pro-form (2), Ser196 (2), AA 1 (1), AA 1-134 (1), AA 287-306 (1), AA 345-359 (1), Cleavage Site (1), Cleaved-Asp315 (1), Cleaved-Asp330 (1), Cleaved-Asp353 (1), Middle Region 1 (1), N-Term,Asp330,active (1), cleaved (1), pSer144 (1)