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Details for Product No. ABIN222880

Cytochrome C, Somatic (CYCS) antibody

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Antigen
Synonyms
CYC, HCS, THC4, cytc, CYCSA, CYCS, ENSMUSG00000058927, cyc, zgc:86706, wu:fk52b01, cyct, hcs, cycs, CG13263, Cyt C, Cyt c, Cyt-c1, CytC-1, CytC1, Cytc, Cytc-d, DC3, Dmel\\CG13263, bln, bs30f07.y1, cyt ... show more
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunoprecipitation (IP)
Pubmed 9 references available
Catalog no. ABIN222880
Quantity 100 µg
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide corresponding to residues surrounding AA 70 of rat cytochrome c
Isotype IgG
Specificity Detects 15 kDa cytochrome c in samples from human/mouse/rat origins
Purification Affinity purified
Alternative Name Cytochrome c
Background Cytochrome c (m.w. 12,500) is an electron transport protein from mitochondria. It is released from mitochondria to cytoplasm during the early stages of apoptosis, prior to caspase activation, DNA fragmentation, and loss of membrane potential. The cytoplasmic cytochrome c is associated with Apaf-1 and caspase-9 to activate caspase-3 and other caspases
Gene ID 25310
Research Area Apoptosis/Necrosis, Metabolism, Cytochrome c
Application Notes The antibody can be used for Western blotting (0.5-4 µg/mL) and immunoprecipitation (10-20 µg/mL).
However the optimal conditions should be determined individually.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal
Preservative Thimerosal (Merthiolate)
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Product cited in: Turpin, Lancaster, Darby et al.: "Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance." in: American journal of physiology. Endocrinology and metabolism, Vol. 291, Issue 6, pp. E1341-50, 2006 (PubMed).

Machiya, Shibata, Yamauchi et al.: "Enhanced expression of MafB inhibits macrophage apoptosis induced by cigarette smoke exposure." in: American journal of respiratory cell and molecular biology, Vol. 36, Issue 4, pp. 418-26, 2007 (PubMed).

Kuhn, Chen, Voorhees et al.: "Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma." in: Blood, Vol. 110, Issue 9, pp. 3281-90, 2007 (PubMed).

Chen, Baydoun, Xu et al.: "Lysophosphatidic acid protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 1, pp. 135-45, 2008 (PubMed).

Crowe, Turpin, Ke et al.: "Metabolic remodeling in adipocytes promotes ciliary neurotrophic factor-mediated fat loss in obesity." in: Endocrinology, Vol. 149, Issue 5, pp. 2546-56, 2008 (PubMed).

Zhao, Chen, Lu et al.: "TIP30 induces apoptosis under oxidative stress through stabilization of p53 messenger RNA in human hepatocellular carcinoma." in: Cancer research, Vol. 68, Issue 11, pp. 4133-41, 2008 (PubMed).

Lan, Gorke, Rau et al.: "Hepatitis C virus infection sensitizes human hepatocytes to TRAIL-induced apoptosis in a caspase 9-dependent manner." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 7, pp. 4926-35, 2008 (PubMed).

Gallentine, Hunnicutt, Husain: "Levetiracetam in children with refractory status epilepticus." in: Epilepsy & behavior : E&B, 2008 (PubMed).

Hurst-Kennedy, Zhong, Gupta et al.: "24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: A signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis." in: The Journal of steroid biochemistry and molecular biology, 2010 (PubMed).

Alternatives for antigen "Cytochrome C, Somatic (CYCS)", type "Antibodies"
Hosts (98), (78), (7), (4)
Reactivities (118), (73), (68), (40), (22), (19), (16), (13), (12), (9), (9), (7), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applications (133), (59), (41), (40), (31), (28), (21), (21), (10), (10), (6), (6), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Conjugates (15), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (8), (5), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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