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Cytochrome C antibody (Cytochrome C, Somatic)

Details for Product anti-CYCS Antibody No. ABIN222880, Supplier: Log in to see
Antigen
  • cyct
  • cyc
  • hcs
  • CYCS
  • cycs
  • CYC
  • CG13263
  • Cyt C
  • Cyt c
  • Cyt-c1
  • CytC-1
  • CytC1
  • Cytc
  • Cytc-d
  • DC3
  • Dmel\\CG13263
  • bln
  • bs30f07.y1
  • cyt c
  • cyt c-d
  • cyt-c-d
  • cyt.c
  • cytochrome c
  • dc3
  • ms(2)04445
  • pDMc02
  • CG17903
  • Cyt-c2
  • CytC-2
  • Cytc-p
  • DC4
  • DMc01
  • Dmel\\CG17903
  • cyt c-p
  • cyt-c-p
  • cyt-c2
  • dc4
  • pDMc01
  • HCS
  • THC4
  • cytc
  • CYCSA
  • wu:fk52b01
  • zgc:86706
  • ENSMUSG00000058927
Reactivity
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
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104
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10
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1
1
1
1
1
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1
Host
Rabbit
134
110
7
2
Clonality
Polyclonal
Conjugate
This Cytochrome C antibody is un-conjugated
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9
4
2
2
2
1
1
1
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1
Application
Immunoprecipitation (IP), Western Blotting (WB)
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15
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11
6
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4
4
3
3
3
2
1
1
1
1
1
1
1
1
Supplier
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Immunogen Synthetic peptide corresponding to residues surrounding amino acid 70 of rat cytochrome c
Blocking Peptide Blocking peptide for this product available: ABIN412696
Isotype IgG
Specificity The cytochrome c antibody detects the 12.6 kDa cytochrome c from human, mouse, and rat samples.
Purification Affinity purified
Alternative Name Cytochrome C (CYCS Antibody Abstract)
Background Cytochrome c (m.w. 12,500) is an electron transport protein from mitochondria. It is released from mitochondria to cytoplasm during the early stages of apoptosis, prior to caspase activation, DNA fragmentation, and loss of membrane potential. The cytoplasmic cytochrome c is associated with Apaf-1 and caspase-9 to activate caspase-3 and other caspases
Synonyms: CYCS, CYC
Gene ID 25310
NCBI Accession NP_036972
Research Area Apoptosis/Necrosis, Metabolism
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Western blotting (0.5-4 μg/mL) and Immunoprecipitation (10-20 μg/mL).
3T3 cell lysate, and rat kidney tissue lysate can be used as positive controls.
Comment

Country of Animal Origin: China

Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer 100 μg (0.2 mg/mL) affinity purified rabbit anti-Cytochrome c polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Cytochrome C antibody (Cytochrome C, Somatic) (ABIN222880) Western blot analysis of cytochrome c in Jurkat (left lane) and 3T3 (right lane) cell...
Product cited in: Hurst-Kennedy, Zhong, Gupta et al.: "24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: A signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis." in: The Journal of steroid biochemistry and molecular biology, 2010 (PubMed).

Gallentine, Hunnicutt, Husain: "Levetiracetam in children with refractory status epilepticus." in: Epilepsy & behavior : E&B, 2008 (PubMed).

Lan, Gorke, Rau et al.: "Hepatitis C virus infection sensitizes human hepatocytes to TRAIL-induced apoptosis in a caspase 9-dependent manner." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 7, pp. 4926-35, 2008 (PubMed).

Shimamura, Fujisawa, Husain et al.: "Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 7, pp. 4656-65, 2008 (PubMed).

Zhao, Chen, Lu et al.: "TIP30 induces apoptosis under oxidative stress through stabilization of p53 messenger RNA in human hepatocellular carcinoma." in: Cancer research, Vol. 68, Issue 11, pp. 4133-41, 2008 (PubMed).

Crowe, Turpin, Ke et al.: "Metabolic remodeling in adipocytes promotes ciliary neurotrophic factor-mediated fat loss in obesity." in: Endocrinology, Vol. 149, Issue 5, pp. 2546-56, 2008 (PubMed).

Chen, Baydoun, Xu et al.: "Lysophosphatidic acid protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 1, pp. 135-45, 2008 (PubMed).

Kuhn, Chen, Voorhees et al.: "Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma." in: Blood, Vol. 110, Issue 9, pp. 3281-90, 2007 (PubMed).

Machiya, Shibata, Yamauchi et al.: "Enhanced expression of MafB inhibits macrophage apoptosis induced by cigarette smoke exposure." in: American journal of respiratory cell and molecular biology, Vol. 36, Issue 4, pp. 418-26, 2007 (PubMed).

Turpin, Lancaster, Darby et al.: "Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance." in: American journal of physiology. Endocrinology and metabolism, Vol. 291, Issue 6, pp. E1341-50, 2006 (PubMed).