Cytochrome C, Somatic (CYCS) antibody

Details for Product No. ABIN222881
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Antigen
Synonyms
cyct, cyc, hcs, CYCS, cycs, CYC, CG13263, Cyt C, Cyt c, Cyt-c1, CytC-1, CytC1, Cytc, Cytc-d, DC3, Dmel\\CG13263, bln, bs30f07.y1, cyt c, cyt c-d, cyt-c-d, cyt.c, cytochrome c, dc3, ms(2)04445, pDMc02, ... show more
cyct, cyc, hcs, CYCS, cycs, CYC, CG13263, Cyt C, Cyt c, Cyt-c1, CytC-1, CytC1, Cytc, Cytc-d, DC3, Dmel\\CG13263, bln, bs30f07.y1, cyt c, cyt c-d, cyt-c-d, cyt.c, cytochrome c, dc3, ms(2)04445, pDMc02, CG17903, Cyt-c2, CytC-2, Cytc-p, DC4, DMc01, Dmel\\CG17903, cyt c-p, cyt-c-p, cyt-c2, dc4, pDMc01, HCS, THC4, cytc, CYCSA, wu:fk52b01, zgc:86706, ENSMUSG00000058927 show less
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(117), (69), (64), (31), (19), (15), (13), (12), (12), (7), (5), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(108), (60), (7), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(11), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunoprecipitation (IP)
(131), (54), (35), (33), (32), (24), (17), (13), (11), (10), (6), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Pubmed 12 references available
Quantity 100 µg
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Catalog No. ABIN222881
357.50 $
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Immunogen Pigeon cytochrome c
Clone 7H8-2C12
Isotype IgG2b
Specificity Detects 12 kDa cytochrome c in denatured human/mouse/rat samples
Purification Affinity purified
Alternative Name Cytochrome c
Background Cytochrome c (m.w. 12,500) is an electron transport protein from mitochondria. It is released from mitochondria to cytoplasm during the early stages of apoptosis, prior to caspase activation, DNA fragmentation, and loss of membrane potential. The cytoplasmic cytochrome c is associated with Apaf-1 and caspase-9 to activate caspase-3 and other caspases.
Research Area Apoptosis/Necrosis, Metabolism, Cytochrome c
Application Notes The antibody can be used in Western blot analysis (0.5-4 µg/mL).
However the optimal conditions should be determined individually.
The antibody detects a 12.0 kDa protein corresponding to the apparent molecular weight of cytochrome c.
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/mL
Buffer PBS containing 50 % glycerol, 0.5 % BSA and 0.01 % Thimerosal and 50 % glycerol
Preservative Thimerosal (Merthiolate)
Precaution of Use This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
Storage -20 °C/-80 °C
Storage Comment For long-term storage, aliquot and freeze at -70 °C.
Expiry Date 12 months
Supplier Images
anti-Cytochrome C, Somatic (CYCS) antibody Western blot anlaysis of cytochrome c with Jurkat cell lysate. Cytochrome
Product cited in: Ahmed, Alcock, Chendil et al.: "Restoration of transforming growth factor-beta signaling enhances radiosensitivity by altering the Bcl-2/Bax ratio in the p53 mutant pancreatic cancer cell line MIA PaCa-2." in: The Journal of biological chemistry, Vol. 277, Issue 3, pp. 2234-46, 2002 (PubMed).

Beaupre, Cepero, Obeng et al.: "R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways." in: Molecular cancer therapeutics, Vol. 3, Issue 2, pp. 179-86, 2004 (PubMed).

Turpin, Lancaster, Darby et al.: "Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance." in: American journal of physiology. Endocrinology and metabolism, Vol. 291, Issue 6, pp. E1341-50, 2006 (PubMed).

Machiya, Shibata, Yamauchi et al.: "Enhanced expression of MafB inhibits macrophage apoptosis induced by cigarette smoke exposure." in: American journal of respiratory cell and molecular biology, Vol. 36, Issue 4, pp. 418-26, 2007 (PubMed).

Jones, Barsby, Cohen et al.: "HIV-1 Vpr causes neuronal apoptosis and in vivo neurodegeneration." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 14, pp. 3703-11, 2007 (PubMed).

Chen, Baydoun, Xu et al.: "Lysophosphatidic acid protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 1, pp. 135-45, 2008 (PubMed).

Liu, Hu, Shi et al.: "Up-regulation of p21 and TNF-alpha is mediated in lycorine-induced death of HL-60 cells." in: Cancer cell international, Vol. 10, pp. 25, 2010 (PubMed).

Liang, Xu, Yin et al.: "Steroidogenic factor-1 is required for TGF-beta3-mediated 17beta-estradiol synthesis in mouse ovarian granulosa cells." in: Endocrinology, Vol. 152, Issue 8, pp. 3213-25, 2011 (PubMed).

Molouki, Yusoff: "NDV-induced apoptosis in absence of Bax; evidence of involvement of apoptotic proteins upstream of mitochondria." in: Virology journal, Vol. 9, Issue 1, pp. 179, 2012 (PubMed).

General Saxena, Ansari, Kumar et al.: "Patulin causes DNA damage leading to cell cycle arrest and apoptosis through modulation of Bax, p(53) and p(21/WAF1) proteins in skin of mice." in: Toxicology and applied pharmacology, Vol. 234, Issue 2, pp. 192-201, 2009 (PubMed).

Zagurovskaya, Shareef, Das et al.: "EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells." in: Oncogene, Vol. 28, Issue 8, pp. 1121-31, 2009 (PubMed).

Juenemann, Weisse, Reichmann et al.: "Modulation of Mutant Huntingtin N-Terminal Cleavage and Its Effect on Aggregation and Cell Death." in: Neurotoxicity research, 2010 (PubMed).

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